Rabbit anti-Human NGF  Monoclonal Antibody | anti-NGF  antibody

Rabbit anti Human NGF  Monoclonal Antibody

Cat. Num. AAA2544157

• Gene Names: NGF; NGFB; HSAN5; Beta-NGF
• Reactivity: Human
• Applications: Immunohistochemistry
• Synonyms: NGF ; Monoclonal Antibody; Rabbit anti Human NGF Monoclonal Antibody; anti-NGF antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 241

• Applicable Applications for anti-NGF antibody: Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 5-20 mug/mL
• Immunogen: Recombinant Human NGF/NGFB protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-NGF  antibody

Nerve growth factor (NGF) is important for the development and maintenance of the sympathetic and sensory nervous systems. NGF protein was identified as a large complex consisting of three non-covalently linked subunits, alpha, beta, and gamma, among which, the beta subunit, called beta-NGF (beta-NGF), was demonstrated to exhibits the growth stimulating activity of NGF protein. NGFB/beta-NGF gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. NGF protein acts via at least two receptors on the surface of cells (TrkA and p75 receptors) to regulate neuronal survival, promote neurite outgrowth, and up-regulate certain neuronal functions such as mediation of pain and inflammation. In addition, previous studies indicated that NGF may also have an important role in the regulation of the immune system.

NCBI and Uniprot Product Information

• NCBI GI #: 823673642
• NCBI GeneID: 4803
• Molecular Weight: 26,959 Da
• NCBI Official Full Name: NGF, partial
• NCBI Official Synonym Full Names: nerve growth factor
• NCBI Official Symbol: NGF
• NCBI Official Synonym Symbols: NGFB; HSAN5; Beta-NGF
• NCBI Protein Information: beta-nerve growth factor
• UniProt Protein Name: Beta-nerve growth factor
• UniProt Gene Name: NGF
• UniProt Synonym Gene Names: NGFB; Beta-NGF
• UniProt Entry Name: NGF_HUMAN

NCBI Description

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

Uniprot Description

NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: endosome; extracellular region; Golgi lumen

Molecular Function: growth factor activity; metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; protein binding

Biological Process: activation of MAPKK activity; caspase activation; cell-cell signaling; induction of apoptosis via death domain receptors; microtubule-based movement; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of neuron apoptosis; nerve growth factor processing; nerve growth factor receptor signaling pathway; neurite morphogenesis; phosphoinositide-mediated signaling; positive regulation of apoptosis; positive regulation of axonogenesis; positive regulation of Ras protein signal transduction; regulation of caspase activity; regulation of neuron differentiation; transmembrane receptor protein tyrosine kinase signaling pathway

Disease: Neuropathy, Hereditary Sensory And Autonomic, Type V