Rabbit anti-Human TFRC  Monoclonal Antibody | anti-TFRC  antibody

Rabbit anti Human TFRC  Monoclonal Antibody

Cat. Num. AAA2544145

• Gene Names: TFRC; T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
• Reactivity: Human
• Applications: Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: TFRC ; Monoclonal Antibody; Rabbit anti Human TFRC Monoclonal Antibody; anti-TFRC antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 679

• Applicable Applications for anti-TFRC antibody: Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cyometry (FC/FACS)
• Application Notes: Flow Cytometry: 0.5-2 mug/Test; ICC/IF: 10-25 mug/mL
• Immunogen: Recombinant Human Transferrin Receptor/TFRC/CD71 protein
• Buffer: 0.2 mum filtered solution in PBS
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-TFRC  antibody

Mouse transferrin receptor protein 1, also known as transferrin receptor, Trfr, p90, CD71 and TFRC, is a single-pass type II membrane protein which belongs to the peptidase M28 family and M28B subfamily. TFRC/CD71 is a membrane-bound protein expressed in larger amounts in proliferating. The specific expression of TFRC can represent a tool or a therapeutic target in solid tumours expressing this antigen. Transferrin receptor is necessary for development of erythrocytes and the nervous system. TFRC/CD71 is regulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation. TFRC/CD71 represents a marker of malignant transformation in the pancreas that could be applied as potential therapeutic target.

NCBI and Uniprot Product Information

• NCBI GI #: 927928764
• NCBI GeneID: 7037
• NCBI GenBank Nucleotide #: NM_001313965.1
• Molecular Weight: 84,871 Da
• NCBI Official Full Name: transferrin receptor protein 1 isoform 2
• NCBI Official Synonym Full Names: transferrin receptor
• NCBI Official Symbol: TFRC
• NCBI Official Synonym Symbols: T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
• NCBI Protein Information: transferrin receptor protein 1
• UniProt Protein Name: Transferrin receptor protein 1
• UniProt Gene Name: TFRC
• UniProt Synonym Gene Names: TR; TfR; TfR1; Trfr; sTfR
• UniProt Entry Name: TFR1_HUMAN

NCBI Description

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

Uniprot Description

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome

Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity

Biological Process: positive regulation of B cell proliferation; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell proliferation; transferrin transport

Disease: Immunodeficiency 46