Rabbit anti-Human IGF1R  Monoclonal Antibody | anti-IGF1R  antibody

Rabbit anti Human IGF1R  Monoclonal Antibody

Cat. Num. AAA2543867

• Gene Names: IGF1R; IGFR1
• Reactivity: Human
• Applications: Immunocytochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: IGF1R ; Monoclonal Antibody; Rabbit anti Human IGF1R Monoclonal Antibody; anti-IGF1R antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 127

• Applicable Applications for anti-IGF1R antibody: Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cyometry (FC/FACS)
• Application Notes: Flow Cytometry: 0.5-2 mug/Test; ICC/IF: 10-25 mug/mL
• Immunogen: Recombinant Human IGF1R/CD221 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-IGF1R  antibody

The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits, and among which, the alpha subunit is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1R signalling pathway is activated in the mammalian nervous system from early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signalling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

NCBI and Uniprot Product Information

• NCBI GI #: 2555166
• NCBI GeneID: 443515
• NCBI Official Full Name: IGF1R, partial
• NCBI Official Symbol: IGF1R
• NCBI Official Synonym Symbols: IGFR1
• NCBI Protein Information: insulin like growth factor 1 receptor; insulin-like growth factor I receptor; insulin-like growth factor type 1 receptor