Mouse anti-Human Interferon beta/IFN-beta/IFNB Monoclonal Antibody | anti-IFN-beta/IFNB antibody

Mouse anti Human Interferon beta/IFN-beta/IFNB Monoclonal Antibody

Cat. Num. AAA2543451

• Gene Names: IFNB1; IFB; IFF; IFNB; IFN-beta
• Reactivity: Human
• Applications: ELISA
• Synonyms: Interferon beta/IFN-beta/IFNB; Monoclonal Antibody; Mouse anti Human Interferon beta/IFN-beta/IFNB Monoclonal Antibody; anti-IFN-beta/IFNB antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Sequence Length: 187

• Applicable Applications for anti-IFN-beta/IFNB antibody: ELISA (EIA)
• Application Notes: ELISA: 0.5-1 mug/mL. This antibody can be used at 0.5-1 mug/mL with the appropriate secondary reagents to detect Human IFNB. The detection limit for Human IFNB is 0.16 ng/well.
• Immunogen: Recombinant Human IFNB protein
• Buffer: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human IFN-beta (rh IFNB; NP_002167.1; Met 1-Asn 187). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 4504603
• NCBI GeneID: 3456
• NCBI GenBank Nucleotide #: NM_002176.3
• Molecular Weight: 22,294 Da
• NCBI Official Full Name: interferon beta
• NCBI Official Synonym Full Names: interferon beta 1
• NCBI Official Symbol: IFNB1
• NCBI Official Synonym Symbols: IFB; IFF; IFNB; IFN-beta
• NCBI Protein Information: interferon beta
• UniProt Protein Name: Interferon beta
• UniProt Gene Name: IFNB1
• UniProt Synonym Gene Names: IFB; IFNB; IFN-beta
• UniProt Entry Name: IFNB_HUMAN

NCBI Description

This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]

Uniprot Description

IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: extracellular region; extracellular space

Molecular Function: chloramphenicol O-acetyltransferase activity; cytokine activity; interferon-alpha/beta receptor binding

Biological Process: B cell activation during immune response; B cell differentiation; B cell proliferation; blood coagulation; cell surface receptor linked signal transduction; defense response to virus; humoral immune response; natural killer cell activation during immune response; negative regulation of T cell differentiation; negative regulation of viral genome replication; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of transcription from RNA polymerase II promoter; response to exogenous dsRNA; T cell activation during immune response