Mouse anti-Human SerpinF2/AAP Monoclonal Antibody | anti-SerpinF2/AAP antibody

Mouse anti Human SerpinF2/AAP Monoclonal Antibody

Cat. Num. AAA2543314

• Gene Names: SERPINF2; AAP; API; PLI; A2AP; ALPHA-2-PI
• Reactivity: Human
• Applications: ELISA
• Synonyms: SerpinF2/AAP; Monoclonal Antibody; Mouse anti Human SerpinF2/AAP Monoclonal Antibody; anti-SerpinF2/AAP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Sequence Length: 491

• Applicable Applications for anti-SerpinF2/AAP antibody: ELISA (EIA)
• Application Notes: ELISA: 0.5-1 mug/mL. This antibody can be used at 0.5-1 mug/mL with the appropriate secondary reagents to detect Human SerpinF2. The detection limit for Human SerpinF2 is approximately 0.039 ng/well.
• Immunogen: Recombinant Human SerpinF2 protein
• Buffer: This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human SerpinF2 (rh SerpinF2; NP_000925.2; Met 1-Lys 491). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -70 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

NCBI and Uniprot Product Information

• NCBI GI #: 21594846
• NCBI GeneID: 5345
• Molecular Weight: 47,907 Da
• NCBI Official Full Name: SERPINF2 protein
• NCBI Official Synonym Full Names: serpin family F member 2
• NCBI Official Symbol: SERPINF2
• NCBI Official Synonym Symbols: AAP; API; PLI; A2AP; ALPHA-2-PI
• NCBI Protein Information: alpha-2-antiplasmin
• UniProt Protein Name: Alpha-2-antiplasmin
• UniProt Gene Name: SERPINF2
• UniProt Synonym Gene Names: AAP; PLI; Alpha-2-AP; Alpha-2-PI
• UniProt Entry Name: A2AP_HUMAN

NCBI Description

This gene encodes a member of the serpin family of serine protease inhibitors. The protein is a major inhibitor of plasmin, which degrades fibrin and various other proteins. Consequently, the proper function of this gene has a major role in regulating the blood clotting pathway. Mutations in this gene result in alpha-2-plasmin inhibitor deficiency, which is characterized by severe hemorrhagic diathesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Uniprot Description

SERPINF2: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. Defects in SERPINF2 are the cause of alpha-2-plasmin inhibitor deficiency (APLID). APLID is an autosomal recessive disorder resulting in severe hemorrhagic diathesis. Belongs to the serpin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17p13

Cellular Component: cell surface; extracellular region; extracellular space; fibrinogen complex

Molecular Function: endopeptidase inhibitor activity; protease binding; protein binding; protein homodimerization activity; serine-type endopeptidase inhibitor activity

Biological Process: blood vessel morphogenesis; collagen fibril organization; fibrinolysis; negative regulation of fibrinolysis; platelet degranulation; positive regulation of cell differentiation; positive regulation of collagen biosynthetic process; positive regulation of JNK cascade; positive regulation of smooth muscle cell proliferation; positive regulation of stress fiber formation; positive regulation of transcription from RNA polymerase II promoter; renin-angiotensin regulation of blood vessel size

Disease: Alpha-2-plasmin Inhibitor Deficiency