Rabbit SPTAN1 Polyclonal Antibody | anti-SPTAN1 antibody

SPTAN1 Polyclonal Antibody

Cat. Num. AAA2525361

• Gene Names: SPTAN1; NEAS; EIEE5; SPTA2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: SPTAN1; Polyclonal Antibody; SPTAN1 Polyclonal Antibody; NEAS; EIEE5; SPTA2; anti-SPTAN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2mg/mL (varies by lot)
• Sequence Length: 2452

• Applicable Applications for anti-SPTAN1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:30-1:150
• Immunogen: Synthetic peptide of human SPTAN1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human liver cancer tissue using SPTAN1 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-SPTAN1 antibody

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation.

NCBI and Uniprot Product Information

• NCBI GI #: 306966132
• NCBI GeneID: 6709
• NCBI Accession #: NP_001182461.1
• NCBI GenBank Nucleotide #: NM_001195532.1
• Molecular Weight: 282,282 Da
• NCBI Official Full Name: spectrin alpha chain, non-erythrocytic 1 isoform 3
• NCBI Official Synonym Full Names: spectrin, alpha, non-erythrocytic 1
• NCBI Official Symbol: SPTAN1
• NCBI Official Synonym Symbols: NEAS; EIEE5; SPTA2
• NCBI Protein Information: spectrin alpha chain, non-erythrocytic 1; alpha-II spectrin; alpha-fodrin; fodrin alpha chain; spectrin, non-erythroid alpha chain; spectrin, non-erythroid alpha subunit
• UniProt Protein Name: Spectrin alpha chain, non-erythrocytic 1
• Protein Family: Spectrin
• UniProt Gene Name: SPTAN1
• UniProt Synonym Gene Names: NEAS; SPTA2
• UniProt Entry Name: SPTN1_HUMAN

NCBI Description

Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]

Uniprot Description

SPTAN1: a cytoskeletal protein which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Capable to forming dimers which can further associate to tetramers.

Protein type: Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: microtubule cytoskeleton; spectrin; membrane; intracellular membrane-bound organelle; fascia adherens; Z disc; cytosol; vesicle; lateral plasma membrane

Molecular Function: calmodulin binding; protein binding; spectrin binding; structural constituent of cytoskeleton; protein heterodimerization activity; calcium ion binding; actin binding

Biological Process: axon guidance; actin filament capping; apoptosis; cell structure disassembly during apoptosis

Disease: Epileptic Encephalopathy, Early Infantile, 5