Rabbit anti-Human, Mouse DOCK3; MOCA Polyclonal Antibody | anti-DOCK3 antibody

DOCK3; MOCA Antibody

Cat. Num. AAA2524441

• Gene Names: DOCK3; PBP; MOCA
• Reactivity: Human, Mouse
• Applications: ELISA, Western Blot
• Purity: Antigen affinity purification
• Synonyms: DOCK3; MOCA; Polyclonal Antibody; MOCA Antibody; KIAA0299; PBP; anti-DOCK3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Sequence Length: 2030

• Applicable Applications for anti-DOCK3 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:500-1:5000
• Immunogen: Peptide of DOCK3; MOCA
• Buffer: PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
• Preparation and Storage: Store at -20 degree C. Avoid freeze / thaw cycles

Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 31415870
• NCBI GeneID: 1795
• NCBI Accession #: NP_004938.1
• NCBI GenBank Nucleotide #: NM_004947.4
• Molecular Weight: 233,103 Da
• NCBI Official Full Name: dedicator of cytokinesis protein 3
• NCBI Official Synonym Full Names: dedicator of cytokinesis 3
• NCBI Official Symbol: DOCK3
• NCBI Official Synonym Symbols: PBP; MOCA
• NCBI Protein Information: dedicator of cytokinesis protein 3; modifier of cell adhesion; presenilin-binding protein
• UniProt Protein Name: Dedicator of cytokinesis protein 3
• Protein Family: Dedicator of cytokinesis protein
• UniProt Gene Name: DOCK3
• UniProt Synonym Gene Names: KIAA0299; MOCA; PBP
• UniProt Entry Name: DOCK3_HUMAN

NCBI Description

This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]

Uniprot Description

DOCK3: Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors. A chromosomal aberration involving DOCK3 has been found in a family with early-onset behavioral/developmental disorder with features of attention deficit-hyperactivity disorder and intellectual disability. Inversion inv(3)(p14:q21). The inversion disrupts DOCK3 and SLC9A9. Belongs to the DOCK family.

Protein type: Motility/polarity/chemotaxis; Cell adhesion; GEFs, misc.; GEFs

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: cytoplasm

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; SH3 domain binding

Biological Process: small GTPase mediated signal transduction; positive regulation of GTPase activity