Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CABLES2 Polyclonal Antibody at dilution 1:25)
Rabbit CABLES2 Polyclonal Antibody | anti-CABLES2 antibody
CABLES2 Polyclonal Antibody
Gene Names
CABLES2; ik3-2; C20orf150; dJ908M14.2
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunohistochemistry
Purity
Antigen affinity purification
Synonyms
CABLES2; Polyclonal Antibody; CABLES2 Polyclonal Antibody; ik3-2; C20orf150; dJ908M14.2; anti-CABLES2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen affinity purification
Concentration
1.8mg/mL (varies by lot)
Sequence Length
325
Applicable Applications for anti-CABLES2 antibody
ELISA (EIA), Immunohistochemistry (IHC)
Application Notes
IHC: 1:25-1:100
Immunogen
Synthetic peptide of human CABLES2
Buffer
PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Preparation and Storage
Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CABLES2 Polyclonal Antibody at dilution 1:25)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CABLES2 Polyclonal Antibody at dilution 1:25)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human brain tissue using CABLES2 Polyclonal Antibody at dilution 1:25)
Immunohistochemistry (IHC)
(Immunohistochemistry of paraffin-embedded Human brain tissue using CABLES2 Polyclonal Antibody at dilution 1:25)
Related Product Information for anti-CABLES2 antibody
Cables2 (Cdk5 and ABL1 enzyme substrate 2), also known as Ik3-2, is a 478 amino acid ubiquitously expressed protein that has a C-terminal cyclin box-containing domain, making it a member of the cyclin protein superfamily. A related protein, Cables, forms a trimolecular complex with Cdk5 and c-Abl in vivo, enhances apoptosis induced by overexpression of p53 and may be a tumor suppressor, due to its chromosomal loss of heterozygosity that is found in certain cancers. Cables2 shares 78% sequence similarity with Cables in the region of the cyclin box-containing domain and, in similar functionality, associates with Cdk3, Cdk5 and c-Abl. However, unlike its close relative, Cables2 also contains an N-terminal region that enhances not only p53-mediated cell death, but also p53-independent cell death. This characteristic suggests that the gene encoding Cables2 may also function as a tumor suppressor gene.
Product Categories/Family for anti-CABLES2 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
52,235 Da
NCBI Official Full Name
CABLES2 protein, partial
NCBI Official Synonym Full Names
Cdk5 and Abl enzyme substrate 2
NCBI Official Symbol
CABLES2
NCBI Official Synonym Symbols
ik3-2; C20orf150; dJ908M14.2
NCBI Protein Information
CDK5 and ABL1 enzyme substrate 2; interactor with CDK3 2
UniProt Protein Name
CDK5 and ABL1 enzyme substrate 2
Protein Family
UniProt Gene Name
CABLES2
UniProt Synonym Gene Names
C20orf150; Ik3-2
UniProt Entry Name
CABL2_HUMAN
Uniprot Description
CABLES2: Unknown. Probably involved in G1-S cell cycle transition. Belongs to the cyclin family.
Chromosomal Location of Human Ortholog: 20q13.33
Biological Process: cell division; cell cycle
Research Articles on CABLES2
1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Similar Products
Product Notes
The CABLES2 cables2 (Catalog #AAA2523309) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The CABLES2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CABLES2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). IHC: 1:25-1:100. Researchers should empirically determine the suitability of the CABLES2 cables2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CABLES2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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