Rabbit ADAMTS18 Polyclonal Antibody | anti-ADAMTS18 antibody

ADAMTS18 Polyclonal Antibody

Cat. Num. AAA2523249

• Gene Names: ADAMTS18; KNO2; MMCAT; ADAMTS21
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ADAMTS18; Polyclonal Antibody; ADAMTS18 Polyclonal Antibody; KNO2; ADAMTS21; anti-ADAMTS18 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1mg/mL (varies by lot)
• Sequence Length: 1221

• Applicable Applications for anti-ADAMTS18 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant protein of human ADAMTS18
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human breast cancer tissue using ADAMTS18 Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human cervical cancer tissue using ADAMTS18 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-ADAMTS18 antibody

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.

Product Categories/Family for anti-ADAMTS18 antibody

Cell biology; Epigenetics

NCBI and Uniprot Product Information

• NCBI GI #: 40806187
• NCBI GeneID: 170692
• NCBI Accession #: NP_955387.1
• NCBI GenBank Nucleotide #: NM_199355.2
• Molecular Weight: 119,768 Da
• NCBI Official Full Name: A disintegrin and metalloproteinase with thrombospondin motifs 18 preproprotein
• NCBI Official Synonym Full Names: ADAM metallopeptidase with thrombospondin type 1 motif, 18
• NCBI Official Symbol: ADAMTS18
• NCBI Official Synonym Symbols: KNO2; MMCAT; ADAMTS21
• NCBI Protein Information: A disintegrin and metalloproteinase with thrombospondin motifs 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 18; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 21; disintegrin and metalloprotease-like protein
• UniProt Protein Name: A disintegrin and metalloproteinase with thrombospondin motifs 18
• Protein Family: A disintegrin and metalloproteinase with thrombospondin motifs
• UniProt Gene Name: ADAMTS18
• UniProt Synonym Gene Names: ADAMTS21; ADAM-TS 18; ADAM-TS18; ADAMTS-18
• UniProt Entry Name: ATS18_HUMAN

NCBI Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene has a high sequence similarity to the protein encoded by gene ADAMTS16, another family member. It is thought to function as a tumor suppressor. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

ADAMTS18: Defects in ADAMTS18 are the cause of Knobloch syndrome type 2 (KNO2). A developmental disorder primarily characterized by typical eye abnormalities, including high myopia, cataracts, dislocated lens, vitreoretinal degeneration, and retinal detachment, with occipital skull defects, which can range from occipital encephalocele to occult cutis aplasia. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.24.-; Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis; Protease

Chromosomal Location of Human Ortholog: 16q23

Cellular Component: proteinaceous extracellular matrix

Molecular Function: zinc ion binding; metalloendopeptidase activity

Biological Process: eye development; proteolysis

Disease: Microcornea, Myopic Chorioretinal Atrophy, And Telecanthus