Rabbit ALG9 Polyclonal Antibody | anti-ALG9 antibody

ALG9 Polyclonal Antibody

Cat. Num. AAA2521476

• Gene Names: ALG9; CDG1L; DIBD1; LOH11CR1J
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: ALG9; Polyclonal Antibody; ALG9 Polyclonal Antibody; CDG1L; DIBD1; LOH11CR1J; anti-ALG9 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.1mg/mL (varies by lot)
• Sequence Length: 447

• Applicable Applications for anti-ALG9 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:50-1:200
• Immunogen: Recombinant protein of human ALG9
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human lymphoma tissue using ALG9 Polyclonal Antibody at dilution 1:30)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ALG9 Polyclonal Antibody at dilution 1:30)

Related Product Information for anti-ALG9 antibody

This gene encodes an alpha-1, 2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 118026937
• NCBI GeneID: 79796
• NCBI Accession #: NP_001071159.1
• NCBI GenBank Nucleotide #: NM_001077691.1
• Molecular Weight: 51,743 Da
• NCBI Official Full Name: alpha-1,2-mannosyltransferase ALG9 isoform c
• NCBI Official Synonym Full Names: ALG9, alpha-1,2-mannosyltransferase
• NCBI Official Symbol: ALG9
• NCBI Official Synonym Symbols: CDG1L; DIBD1; LOH11CR1J
• NCBI Protein Information: alpha-1,2-mannosyltransferase ALG9; asparagine-linked glycosylation 9 homolog (S. cerevisiae, alpha- 1,2-mannosyltransferase); asparagine-linked glycosylation 9 homolog (yeast, alpha- 1,2-mannosyltransferase); asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog; asparagine-linked glycosylation protein 9 homolog; disrupted in bipolar affective disorder 1; disrupted in bipolar disorder protein 1; dol-P-Man dependent alpha-1,2-mannosyltransferase; dol-P-Man:Man(6)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase; dolichyl-P-Man:Man(6)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase; dolichyl-P-Man:Man(8)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase; loss of heterozygosity, 11, chromosomal region 1 gene J product
• UniProt Protein Name: Alpha-1,2-mannosyltransferase ALG9
• Protein Family: Alpha-1,2-mannosyltransferase
• UniProt Gene Name: ALG9
• UniProt Synonym Gene Names: DIBD1
• UniProt Entry Name: ALG9_HUMAN

NCBI Description

This gene encodes an alpha-1,2-mannosyltransferase enzyme that functions in lipid-linked oligosaccharide assembly. Mutations in this gene result in congenital disorder of glycosylation type Il. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

ALG9: Catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides. A chromosomal aberration involving ALG9 is found in a family with bipolar affective disorder. Translocation t(9;11)(p24;q23). However, common variations in ALG9 do not play a major role in predisposition to bipolar affective disorder. Defects in ALG9 are the cause of congenital disorder of glycosylation type 1L (CDG1L). CDGs are a family of severe inherited diseases caused by a defect in protein N- glycosylation. They are characterized by under-glycosylated serum proteins. These multisystem disorders present with a wide variety of clinical features, such as disorders of the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. Belongs to the glycosyltransferase 22 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.4.1.261; Transferase; EC 2.4.1.259; Membrane protein, integral; Membrane protein, multi-pass; Glycan Metabolism - N-glycan biosynthesis

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: mannosyltransferase activity

Biological Process: cellular protein metabolic process; dolichol-linked oligosaccharide biosynthetic process; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification

Disease: Congenital Disorder Of Glycosylation, Type Il