Rabbit GPAM Polyclonal Antibody | anti-GPAM antibody

GPAM Polyclonal Antibody

Cat. Num. AAA2517470

• Gene Names: GPAM; GPAT; GPAT1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: GPAM; Polyclonal Antibody; GPAM Polyclonal Antibody; GPAT; GPAT1; anti-GPAM antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 2.8mg/mL (varies by lot)
• Sequence Length: 828

• Applicable Applications for anti-GPAM antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:300
• Immunogen: Recombinant protein of human GPAM
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using GPAM Polyclonal Antibody at dilution 1:60)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human gastric cancer tissue using GPAM Polyclonal Antibody at dilution 1:60)

Related Product Information for anti-GPAM antibody

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 350276140
• NCBI GeneID: 57678
• NCBI Accession #: NP_001231878.1
• NCBI GenBank Nucleotide #: NM_001244949.1
• Molecular Weight: 93,795 Da
• NCBI Official Full Name: glycerol-3-phosphate acyltransferase 1, mitochondrial
• NCBI Official Synonym Full Names: glycerol-3-phosphate acyltransferase, mitochondrial
• NCBI Official Symbol: GPAM
• NCBI Official Synonym Symbols: GPAT; GPAT1
• NCBI Protein Information: glycerol-3-phosphate acyltransferase 1, mitochondrial; GPAT-1; glycerol 3-phosphate acyltransferase, mitochondrial
• UniProt Protein Name: Glycerol-3-phosphate acyltransferase 1, mitochondrial
• UniProt Gene Name: GPAM
• UniProt Synonym Gene Names: GPAT1; KIAA1560; GPAT-1
• UniProt Entry Name: GPAT1_HUMAN

NCBI Description

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]

Uniprot Description

GPAM: glycerol-3-phosphate acyltransferase is an integral multi-pass enzyme of the mitochondrial outer membrane. It performs the first step in de novo phospholipid biosynthesis. Member of the phospholipid and glycerol acyltransferase family

Protein type: Membrane protein, multi-pass; Mitochondrial; Transferase; Membrane protein, integral; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; EC 2.3.1.15

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: mitochondrial outer membrane; mitochondrial inner membrane; plasma membrane; integral to membrane

Molecular Function: glycerol-3-phosphate O-acyltransferase activity

Biological Process: regulation of cytokine secretion; acyl-CoA metabolic process; glycerophospholipid biosynthetic process; triacylglycerol biosynthetic process; positive regulation of multicellular organism growth; cellular lipid metabolic process; fatty acid metabolic process; positive regulation of activated T cell proliferation; phospholipid metabolic process; fatty acid homeostasis; response to glucose stimulus; phosphatidic acid biosynthetic process; CDP-diacylglycerol biosynthetic process; defense response to virus; phospholipid homeostasis