Immunohistochemistry (IHC)
(Anti-ACACB / ACC2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Goat ACACB / ACC2 Polyclonal Antibody | anti-ACACB antibody
Goat Polyclonal to Mouse ACACB / ACC2
Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the calculated size of 277kD according to NP_001084.3. Therefore we...
Immunohistochemistry (IHC)
(Anti-ACACB / ACC2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
Immunohistochemistry (IHC)
(Anti-ACACB / ACC2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)
NCBI and Uniprot Product Information
NCBI Description
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
Uniprot Description
ACC2: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing.
Protein type: Lipid Metabolism - fatty acid biosynthesis; Ligase; EC 6.4.1.2; Carbohydrate Metabolism - pyruvate; Mitochondrial; Carbohydrate Metabolism - propanoate; EC 6.3.4.14
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: mitochondrial outer membrane; mitochondrion; endomembrane system; nucleus; cytosol
Molecular Function: protein binding; acetyl-CoA carboxylase activity; metal ion binding; biotin carboxylase activity; ATP binding; biotin binding
Biological Process: response to drug; vitamin metabolic process; acetyl-CoA metabolic process; energy reserve metabolic process; positive regulation of cellular metabolic process; carnitine shuttle; cellular lipid metabolic process; response to organic cyclic substance; biotin metabolic process; negative regulation of fatty acid oxidation; fatty acid biosynthetic process; water-soluble vitamin metabolic process; protein homotetramerization
Research Articles on ACACB
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Product Notes
The ACACB acacb (Catalog #AAA248196) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Polyclonal to Mouse ACACB / ACC2 reacts with Bat, Gibbon, Chimpanzee, Human, Monkey, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's ACACB / ACC2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA (1:16000), IHC-P (5 ug/ml) Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Not yet tested - our routinely used western blotting protocol does not allow detection of proteins as large as the calculated size of 277kD according to NP_001084.3. Therefore we.. Researchers should empirically determine the suitability of the ACACB acacb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ACACB / ACC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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