Rabbit anti-Human SLC2A3 / GLUT3 Polyclonal Antibody | anti-SLC2A3 antibody

Rabbit Polyclonal (IgG) to Human SLC2A3 / GLUT3

Cat. Num. AAA246979

• Gene Names: SLC2A3; GLUT3
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: SLC2A3 / GLUT3; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human SLC2A3 / GLUT3; Anti-SLC2A3 / GLUT3 Antibody (aa447-496) IHC-plus; SLC2A3; Glucose transporter 3; GLUT-3; Glucose transporter GLUT3; Glucose transporter type 3; GLUT3; Human SLC2A3; anti-SLC2A3 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GLUT3 Antibody detects endogenous levels of total GLUT3 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 496

• Applicable Applications for anti-SLC2A3 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA (1:1000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)
• Target Species: Human
• Immunogen Description: Synthetic peptide from human GLUT3 (aa447-496).
• Immunogen: SLC2A3 / GLUT3 antibody was raised against synthetic peptide from human GLUT3 (aa447-496).
• Antigen Modification: aa447-496
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-SLC2A3 / GLUT3 antibody IHC of human tonsil, germinal center. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Western Blot (WB)

(Western blot of extracts from LOVO cells, using GLUT3 Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-SLC2A3 antibody

SLC2a3 (Solute carrier family 2 (Facilitated glucose transporter), Member 3), also known as Glucose transporter 3 (GLUT3), is the third member of the Glucose Transporters family. The product of this appears to be important for tissues with high glucose demand, such as brain or skeletal muscle. Also, SLC2a3 may play a role in the transport of glucose from the placenta to the fetal circulation.

Product Categories/Family for anti-SLC2A3 antibody

Family: Transporter; Subfamily: Sugar transporter

NCBI and Uniprot Product Information

• NCBI GI #: 5902090
• NCBI GeneID: 6515
• NCBI Accession #: NP_008862.1
• NCBI GenBank Nucleotide #: NM_006931.2
• UniProt Accession #: P11169; Q6I9U2; Q9UG15; B2R606; D3DUU6
• Molecular Weight: 53,924 Da
• NCBI Official Full Name: solute carrier family 2, facilitated glucose transporter member 3
• NCBI Official Synonym Full Names: solute carrier family 2 (facilitated glucose transporter), member 3
• NCBI Official Symbol: SLC2A3
• NCBI Official Synonym Symbols: GLUT3
• NCBI Protein Information: solute carrier family 2, facilitated glucose transporter member 3; GLUT-3; glucose transporter type 3, brain
• UniProt Protein Name: Solute carrier family 2, facilitated glucose transporter member 3
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC2A3
• UniProt Synonym Gene Names: GLUT3; GLUT-3
• UniProt Entry Name: GTR3_HUMAN

Uniprot Description

GLUT3: an integral membrane facilitative glucose transporter. One of 13 members of the human equilibrative glucose transport protein family. It???s surface expression is induced by insulin. It is restricted in humans to brain, testis (in the spermatozoa), and skeletal muscle, mostly in triads of slow-twitch fibres. Detected only in the brain of mouse and rat. IHC demonstrates its present in neurons, mainly at the plasma membrane, and to a lesser extent on intracellular vesicles distinct from synaptic vesicles. Present in the a-granules of human platelets, where it is translocated to the cell surface in response to thrombin stimulation. Its surface expression is increased by insulin or insulin growth-factor in cultured L6 muscle cells.

Protein type: Transporter, SLC family; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 12p13.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: glucose transmembrane transporter activity

Biological Process: vitamin metabolic process; hexose transport; carbohydrate metabolic process; L-ascorbic acid metabolic process; pathogenesis; glucose transport; transmembrane transport; water-soluble vitamin metabolic process