Rabbit MRGD / MRGPRD Polyclonal Antibody | anti-MRGD antibody

Rabbit Polyclonal to Human MRGD / MRGPRD

Cat. Num. AAA246837

• Gene Names: MRGPRD; MRGD; TGR7
• Reactivity: Gorilla, Human, Monkey
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: MRGD / MRGPRD; Polyclonal Antibody; Rabbit Polyclonal to Human MRGD / MRGPRD; Anti-MRGD / MRGPRD Antibody (Cytoplasmic Domain) IHC-plus; MRGPRD; Beta-alanine receptor; MRGD; MAS-related GPR; member D; TGR7; Human MRGD; anti-MRGD antibody

• Host: Rabbit
• Reactivity: Gorilla, Human, Monkey
• Clonality: Polyclonal
• Specificity: Human MRGPRD. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 321

• Applicable Applications for anti-MRGD antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (17 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human MRGPRD. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (89%); Marmoset (83%).
• Immunogen Type: Synthetic peptide
• Immunogen: MRGD / MRGPRD antibody was raised against synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human MRGPRD. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (89%); Marmoset (83%).
• Antigen Modification: Cytoplasmic Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-MRGPRD antibody IHC of human brain, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-MRGD / MRGPRD antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-MRGD antibody

MAS-related GPR, member D (MRGPRD), is expressed in the dorsal root ganglia and has been suggested to affect the modulation of neuropathic pain.

Product Categories/Family for anti-MRGD antibody

Family: GPCR; Subfamily: Orphan-A

NCBI and Uniprot Product Information

• NCBI GI #: 42794265
• NCBI GeneID: 116512
• NCBI Accession #: NP_944605.2
• NCBI GenBank Nucleotide #: NM_198923.2
• UniProt Accession #: Q8TDS7; Q8NGK7
• Molecular Weight: 36,118 Da
• NCBI Official Full Name: mas-related G-protein coupled receptor member D
• NCBI Official Synonym Full Names: MAS-related GPR, member D
• NCBI Official Symbol: MRGPRD
• NCBI Official Synonym Symbols: MRGD; TGR7
• NCBI Protein Information: mas-related G-protein coupled receptor member D; beta-alanine receptor; G-protein coupled receptor TGR7; mas-related G protein-coupled MRGD
• UniProt Protein Name: Mas-related G-protein coupled receptor member D
• UniProt Gene Name: MRGPRD
• UniProt Synonym Gene Names: MRGD
• UniProt Entry Name: MRGRD_HUMAN

Uniprot Description

MRGPRD: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: extracellular space; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway