Rabbit RELB Polyclonal Antibody | anti-RELB antibody

Rabbit Polyclonal (IgG) to Human RELB

Cat. Num. AAA246790

• Gene Names: RELB; IREL; I-REL; REL-B
• Reactivity: Gibbon, Gorilla, Human, Monkey, Mouse, Rabbit; Predicted Reactivity: Bat, Bovine, Hamster, Horse (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Western Blot
• Purity: Purified
• Synonyms: RELB; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human RELB; Anti-RELB Antibody IHC-plus; REL-B; Transcription factor RelB; I-Rel; IREL; Human RELB; anti-RELB antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Human, Monkey, Mouse, Rabbit; Predicted Reactivity: Bat, Bovine, Hamster, Horse (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified
• Form/Format: HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
• Sequence Length: 579

• Applicable Applications for anti-RELB antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (1:200), WB (1:2000)
• Target Species: Human
• Immunogen Description: Synthetic peptide (REAAFGGGLLSPGPEAT). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Elephant, Rabbit (100%); Hamster, Bat, Bovine, Horse (94%); Panda, Dog (88%).
• Immunogen Type: Synthetic peptide
• Immunogen: RELB antibody was raised against synthetic peptide (REAAFGGGLLSPGPEAT). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Elephant, Rabbit (100%); Hamster, Bat, Bovine, Horse (94%); Panda, Dog (88%).
• Preparation and Storage: Long term: -20 degree C; Short term: -20 degree C

Immunohistochemistry (IHC)

(Anti-RELB antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Western Blot (WB)

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NCBI and Uniprot Product Information

• NCBI GI #: 35493878
• NCBI GeneID: 5971
• NCBI Accession #: NP_006500.2
• NCBI GenBank Nucleotide #: NM_006509.3
• UniProt Accession #: Q01201; Q6GTX7; Q9UEI7
• Molecular Weight: 62,134 Da
• NCBI Official Full Name: transcription factor RelB
• NCBI Official Synonym Full Names: v-rel avian reticuloendotheliosis viral oncogene homolog B
• NCBI Official Symbol: RELB
• NCBI Official Synonym Symbols: IREL; I-REL; REL-B
• NCBI Protein Information: transcription factor RelB; v-rel reticuloendotheliosis viral oncogene homolog B, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3; v-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
• UniProt Protein Name: Transcription factor RelB
• Protein Family: Antitoxin
• UniProt Gene Name: RELB
• UniProt Entry Name: RELB_HUMAN

Uniprot Description

RELB: a transcription factor of the nuclear factor-kappaB (NFkB) transcription complex. Stimulates promoter activity in the presence NFkB1/NFkB-p50. Plays role in regulation of apoptosis in hepatocellular carcinoma through activation of downstream target genes. Does not associate with DNA or RelA/NFkB-p65.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: nucleoplasm; cytoplasm; microtubule organizing center; cytosol

Molecular Function: protein binding; chromatin binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; antigen processing and presentation; I-kappaB kinase/NF-kappaB cascade; response to cytokine stimulus; T-helper 1 cell differentiation; innate immune response; myeloid dendritic cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; circadian regulation of gene expression; inflammatory response