Rabbit GCGR / Glucagon Receptor Polyclonal Antibody | anti-GCGR antibody

Rabbit Polyclonal to Human GCGR / Glucagon Receptor

Cat. Num. AAA244349

• Gene Names: GCGR; GGR; GL-R
• Reactivity: Gibbon, Human; Predicted Reactivity: Gorilla, Monkey, Bovine, Dog, Hamster, Horse (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GCGR / Glucagon Receptor; Polyclonal Antibody; Rabbit Polyclonal to Human GCGR / Glucagon Receptor; Anti-GCGR / Glucagon Receptor Antibody (N-Terminus) IHC-plus; GCGR; GL-R; Glucagon receptor; GGR; Human GCGR; Glucagon Receptor; anti-GCGR antibody

• Host: Rabbit
• Reactivity: Gibbon, Human; Predicted Reactivity: Gorilla, Monkey, Bovine, Dog, Hamster, Horse (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human Glucagon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 477

• Applicable Applications for anti-GCGR antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (2 - 5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from N-terminal extracellular domain of human Glucagon Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey (95%); Hamster, Bovine, Dog, Horse (90%); Mouse, Rat (85%).
• Immunogen Type: Synthetic peptide
• Immunogen: GCGR / Glucagon Receptor antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human Glucagon Receptor. Percent identity with other species by BLAST analysis: Human, Gibbon (100%); Gorilla, Monkey (95%); Hamster, Bovine, Dog, Horse (90%); Mouse, Rat (85%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GCGR / Glucagon Receptor antibody IHC of human Adipose, Liposarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Human, Adipocyte: Formalin-Fixed Paraffin-Embedded (FFPE))

Immunohistochemistry (IHC)

(Anti-GCGR / Glucagon Receptor antibody IHC of human Prostate, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GCGR / Glucagon Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GCGR antibody

The Glucagon Receptor mediates the effects of glucagon in controlling glucose metabolism by initiating a cascade of events that regulate the amount of glucose released from the liver into the bloodstream. Glucagon generally functions as a counterregulatory hormone, opposing the actions of insulin, in maintaining the levels of blood glucose, particularly in patients with hypoglycemia.

Product Categories/Family for anti-GCGR antibody

Family: GPCR; Subfamily: Glucagon

NCBI and Uniprot Product Information

• NCBI GI #: 4503947
• NCBI GeneID: 2642
• NCBI Accession #: NP_000151.1
• NCBI GenBank Nucleotide #: NM_000160.4
• UniProt Accession #: P47871; Q2M3M5
• Molecular Weight: 54,009 Da
• NCBI Official Full Name: glucagon receptor
• NCBI Official Synonym Full Names: glucagon receptor
• NCBI Official Symbol: GCGR
• NCBI Official Synonym Symbols: GGR; GL-R
• NCBI Protein Information: glucagon receptor
• UniProt Protein Name: Glucagon receptor
• Protein Family: Glucagon receptor
• UniProt Gene Name: GCGR
• UniProt Synonym Gene Names: GL-R
• UniProt Entry Name: GLR_HUMAN

NCBI Description

The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]

Uniprot Description

GCGR: This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 2 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 2; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 17q25

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane; endosome

Molecular Function: guanyl-nucleotide exchange factor activity; peptide hormone binding; glucagon receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; response to starvation; generation of precursor metabolites and energy; exocytosis; hormone-mediated signaling; regulation of blood pressure; energy reserve metabolic process; glucose homeostasis; G-protein signaling, adenylate cyclase activating pathway; response to nutrient; positive regulation of GTPase activity

Disease: Diabetes Mellitus, Noninsulin-dependent