Immunohistochemistry (IHC)
(Anti-GPR65 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Rabbit GPR65 / TDAG8 Polyclonal Antibody | anti-GPR65 antibody
Rabbit Polyclonal to Human GPR65 / TDAG8
Gene Names
GPR65; TDAG8; hTDAG8
Reactivity
HumanPredicted Reactivity: Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Horse, Pig (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
GPR65 / TDAG8; Polyclonal Antibody; Rabbit Polyclonal to Human GPR65 / TDAG8; Anti-GPR65 / TDAG8 Antibody (Cytoplasmic Domain) IHC-plus; GPR65; G-protein coupled receptor 65; Gpcr25; HTDAG8; TDAG8; T-cell death-associated gene 8; Psychosine receptor; G protein-coupled receptor 65; Human GPR65; anti-GPR65 antibody
Host
Rabbit
Reactivity
Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Horse, Pig (at least 90% immunogen sequence identity)
Predicted Reactivity: Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Horse, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human GPR65. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
337
Applicable Applications for anti-GPR65 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (4 - 11 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from 1st cytoplasmic domain of human GPR65. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Panda, Horse, Pig (94%); Bovine, Hamster, Rabbit.
Immunogen Type
Synthetic peptide
Immunogen
GPR65 / TDAG8 antibody was raised against synthetic 16 amino acid peptide from 1st cytoplasmic domain of human GPR65. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bat, Panda, Horse, Pig (94%); Bovine, Hamster, Rabbit, Platypus (88%); Elephant, Opossum (81%).
Antigen Modification
Cytoplasmic Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Immunohistochemistry (IHC)
(Anti-GPR65 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-GPR65 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-GPR65 / TDAG8 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-GPR65 / TDAG8 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-GPR65 / TDAG8 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Immunohistochemistry (IHC)
(Anti-GPR65 / TDAG8 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-GPR65 antibody
GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease.
Product Categories/Family for anti-GPR65 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
39,333 Da
NCBI Official Full Name
psychosine receptor
NCBI Official Synonym Full Names
G protein-coupled receptor 65
NCBI Official Symbol
GPR65
NCBI Official Synonym Symbols
TDAG8; hTDAG8
NCBI Protein Information
psychosine receptor; G-protein coupled receptor 65; T-cell death-associated gene 8 protein
UniProt Protein Name
Psychosine receptor
Protein Family
UniProt Gene Name
GPR65
UniProt Synonym Gene Names
TDAG8
UniProt Entry Name
PSYR_HUMAN
Uniprot Description
GPR65: Receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. May have a role in activation- induced cell death or differentiation of T-cells. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 14q31-q32.1
Cellular Component: integral to plasma membrane; plasma membrane
Molecular Function: G-protein coupled receptor activity
Biological Process: G-protein coupled receptor protein signaling pathway; apoptosis; multicellular organismal development; actin cytoskeleton reorganization; positive regulation of cAMP biosynthetic process; positive regulation of stress fiber formation; immune response; response to acidity
Research Articles on GPR65
Similar Products
Product Notes
The GPR65 gpr65 (Catalog #AAA243998) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human GPR65 / TDAG8 reacts with Human Predicted Reactivity: Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Dog, Horse, Pig (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's GPR65 / TDAG8 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (4 - 11 ug/ml). Researchers should empirically determine the suitability of the GPR65 gpr65 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GPR65 / TDAG8, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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