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Immunohistochemistry (IHC) (Anti-P2RY4 / P2Y4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit P2RY4 / P2Y4 Polyclonal Antibody | anti-P2RY4 antibody

Rabbit Polyclonal to Human P2RY4 / P2Y4

Gene Names
P2RY4; NRU; P2P; UNR; P2Y4
Reactivity
Human
Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
P2RY4 / P2Y4; Polyclonal Antibody; Rabbit Polyclonal to Human P2RY4 / P2Y4; Anti-P2RY4 / P2Y4 Antibody (Extracellular Domain) IHC-plus; P2RY4; p2Y4; p2P; p2Y purinoceptor 4; Pyrimidinergic receptor p2ry4; NRU; Uridine nucleotide receptor; p2RY4; UNR; Human P2RY4; P2Y4; anti-P2RY4 antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Human
Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human P2RY4 / P2Y4. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
1 mg/ml (varies by lot)
Sequence Length
365
Applicable Applications for anti-P2RY4 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (6 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from 2nd extracellular domain of human P2RY4 / P2Y4. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (93%); Monkey, Hamster, Bovine, Pig (80%).
Immunogen Type
Synthetic peptide
Immunogen
P2RY4 / P2Y4 antibody was raised against synthetic 15 amino acid peptide from 2nd extracellular domain of human P2RY4 / P2Y4. Percent identity with other species by BLAST analysis: Human (100%); Gorilla (93%); Monkey, Hamster, Bovine, Pig (80%).
Antigen Modification
Extracellular Domain
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-P2RY4 / P2Y4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-P2RY4 / P2Y4 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-P2RY4 / P2Y4 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-P2RY4 / P2Y4 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-P2RY4 / P2Y4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-P2RY4 / P2Y4 antibody IHC of human Lymph Node, Hodgkins Lymphoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-P2RY4 antibody
The pyrimidinergic receptor P2Y4 (P2RY4) is a member of the Purinergic Receptor subfamily. Membrane-bound P2 receptors mediate the actions of extracellular nucleotides in cell-to-cell signaling.
Product Categories/Family for anti-P2RY4 antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
40,963 Da
NCBI Official Full Name
P2Y purinoceptor 4
NCBI Official Synonym Full Names
pyrimidinergic receptor P2Y, G-protein coupled, 4
NCBI Official Symbol
P2RY4
NCBI Official Synonym Symbols
NRU; P2P; UNR; P2Y4
NCBI Protein Information
P2Y purinoceptor 4; uridine nucleotide receptor
UniProt Protein Name
P2Y purinoceptor 4
Protein Family
UniProt Gene Name
P2RY4
UniProt Synonym Gene Names
NRU; P2Y4; UNR
UniProt Entry Name
P2RY4_HUMAN

NCBI Description

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]

Uniprot Description

P2RY4: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq13

Cellular Component: integral to plasma membrane; basolateral plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: purinergic nucleotide receptor activity, G-protein coupled; UTP-activated nucleotide receptor activity; ATP binding; uridine nucleotide receptor activity

Biological Process: elevation of cytosolic calcium ion concentration; transepithelial chloride transport; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)

Research Articles on P2RY4

Similar Products

Product Notes

The P2RY4 p2ry4 (Catalog #AAA243988) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human P2RY4 / P2Y4 reacts with Human Predicted Reactivity: Gorilla (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's P2RY4 / P2Y4 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (6 ug/ml). Researchers should empirically determine the suitability of the P2RY4 p2ry4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "P2RY4 / P2Y4, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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