Rabbit Leukotriene B4 Receptor / BLT1 Polyclonal Antibody | anti-LTB4R antibody

Rabbit Polyclonal (IgG) to Human Leukotriene B4 Receptor / BLT1

Cat. Num. AAA243711

• Gene Names: LTB4R; BLT1; BLTR; P2Y7; GPR16; LTBR1; P2RY7; CMKRL1; LTB4R1
• Reactivity: Human; Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry, Immunocytochemistry, Western Blot
• Purity: Affinity Purified
• Synonyms: Leukotriene B4 Receptor / BLT1; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human Leukotriene B4 Receptor / BLT1; Anti-Leukotriene B4 Receptor / BLT1 Antibody IHC-plus; BLT; BLTR; Blt-1; Chemokine receptor-like 1; G protein-coupled receptor 16; GPR16; Leukotriene B4 receptor; Leukotriene B4 receptor 1; G-protein coupled receptor 16; LTBR1; p2Y purinoceptor 7; p2Y7; LTB4-R 1; p2RY7; CMKRL1; LTB4-R1; LTB4R1; Human Leukotriene B4 Receptor; BLT1; anti-LTB4R antibody

• Host: Rabbit
• Reactivity: Human; Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity Purified
• Form/Format: TBS pH 7.4, containing 50% glycerol, 0.5 mg/ml BSA, and 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 352

• Applicable Applications for anti-LTB4R antibody: Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)
• Application Notes: ICC, IHC-P (5 ug/ml), WB (1:200)
• Target Species: Human
• Non Reactive Species: Mouse
• Immunogen Description: Human BLT1 receptor amino acids 331-352 (ALEPGPSESLTASSPLKLNELN).
• Immunogen: Leukotriene B4 Receptor / BLT1 antibody was raised against human BLT1 receptor amino acids 331-352 (ALEPGPSESLTASSPLKLNELN).
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.

Immunohistochemistry (IHC)

(Anti-Leukotriene B4 Receptor antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC)

(Anti-Leukotriene B4 Receptor antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of Leukotriene B4 Receptor / BLT1 antibody.)

Related Product Information for anti-LTB4R antibody

BLT1 is a Chemoattractant Receptor that binds the potent chemoattractant leukotriene B4 (LTB4) which is involved in defense against infection. Leukotriene B4 also activates the transcription factor PPAR alpha, resulting in the activation of genes that terminate inflammatory processes (Yokomizo et al., 1997). Although BLT1 shows homology to other P2Y receptors, it does not function as a purinoreceptor (Yokomizo et al., 1997).

Product Categories/Family for anti-LTB4R antibody

Family: GPCR; Subfamily: Chemoattractant

NCBI and Uniprot Product Information

• NCBI GI #: 221218998
• NCBI GeneID: 1241
• NCBI Accession #: NP_001137391.1
• NCBI GenBank Nucleotide #: NM_001143919.2
• UniProt Accession #: Q15722; Q13305; Q53XV5; Q92641; Q9BSU5
• Molecular Weight: 37,557 Da
• NCBI Official Full Name: leukotriene B4 receptor 1
• NCBI Official Synonym Full Names: leukotriene B4 receptor
• NCBI Official Symbol: LTB4R
• NCBI Official Synonym Symbols: BLT1; BLTR; P2Y7; GPR16; LTBR1; P2RY7; CMKRL1; LTB4R1
• NCBI Protein Information: leukotriene B4 receptor 1; LTB4-R1; LTB4-R 1; P2Y purinoceptor 7; chemokine receptor-like 1; G protein-coupled receptor 16; G-protein coupled receptor 16; chemoattractant receptor-like 1; purinergic receptor P2Y, G-protein coupled, 7
• UniProt Protein Name: Leukotriene B4 receptor 1
• Protein Family: Leukotriene B4 receptor
• UniProt Gene Name: LTB4R
• UniProt Synonym Gene Names: BLT; BLT1; BLTR; CMKRL1; GPR16; P2RY7; LTB4-R 1; LTB4-R1; P2Y7
• UniProt Entry Name: LT4R1_HUMAN

Uniprot Description

LTB4R: Receptor for extracellular ATP > UTP and ADP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. May be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. Is a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 14q11.2-q12

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: leukotriene B4 receptor activity; nucleotide binding; leukotriene receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; muscle contraction; immune response; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); cell motility; inflammatory response