Rabbit PTGER2 / EP2 Polyclonal Antibody | anti-PTGER2 antibody

Rabbit Polyclonal to Human PTGER2 / EP2

Cat. Num. AAA243662

• Gene Names: PTGER2; EP2
• Reactivity: Gorilla, Human, Monkey; Predicted Reactivity: Bat (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: PTGER2 / EP2; Polyclonal Antibody; Rabbit Polyclonal to Human PTGER2 / EP2; Anti-PTGER2 / EP2 Antibody (N-Terminus) IHC-plus; PTGER2; EP2 prostaglandin e2 receptor; EP2 prostaglandin receptor; EP2; Pge2-r ep2; PGE2 receptor EP2 subtype; Prostaglandin E receptor 2; Prostanoid EP2 receptor; EP2 receptor; PGE receptor EP2 subtype; Human PTGER2; anti-PTGER2 antibody

• Host: Rabbit
• Reactivity: Gorilla, Human, Monkey; Predicted Reactivity: Bat (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human EP2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 358

• Applicable Applications for anti-PTGER2 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (2 - 7 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 18 amino acid peptide from N-terminal extracellular domain of human EP2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Bat (94%); Marmoset, Hamster (89%).
• Immunogen Type: Synthetic peptide
• Immunogen: PTGER2 / EP2 antibody was raised against synthetic 18 amino acid peptide from N-terminal extracellular domain of human EP2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Bat (94%); Marmoset, Hamster (89%).
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-PTGER2 / EP2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-EP2 antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-PTGER2 / EP2 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-PTGER2 / EP2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-PTGER2 / EP2 antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-PTGER2 antibody

Prostaglandin E Receptor EP2 is a member of the Prostanoid Receptor subfamily. Along with several other receptor subtypes (EP1, EP3, and EP4), it mediates the diverse biological effects of Prostaglandin E2 (PGE2). PGE2 has been implicated in numerous processes, including immune response modulation, male erectile function, induction of labor, cervical cancer, control of blood pressure, asthma, and more recently, Alzheimer's Disease.

Product Categories/Family for anti-PTGER2 antibody

Family: GPCR; Subfamily: Prostanoid

NCBI and Uniprot Product Information

• NCBI GI #: 31881630
• NCBI GeneID: 5732
• NCBI Accession #: NP_000947.2
• NCBI GenBank Nucleotide #: NM_000956.3
• UniProt Accession #: P43116; Q52LG8; D3DSC0
• Molecular Weight: 39,761 Da
• NCBI Official Full Name: prostaglandin E2 receptor EP2 subtype
• NCBI Official Synonym Full Names: prostaglandin E receptor 2 (subtype EP2), 53kDa
• NCBI Official Symbol: PTGER2
• NCBI Official Synonym Symbols: EP2
• NCBI Protein Information: prostaglandin E2 receptor EP2 subtype; prostanoid EP2 receptor; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E receptor 2 (subtype EP2), 53kD
• UniProt Protein Name: Prostaglandin E2 receptor EP2 subtype
• Protein Family: Prostaglandin E2 receptor
• UniProt Gene Name: PTGER2
• UniProt Synonym Gene Names: PGE receptor EP2 subtype; PGE2 receptor EP2 subtype
• UniProt Entry Name: PE2R2_HUMAN

NCBI Description

This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]

Uniprot Description

PTGER2: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 14q22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: prostaglandin E receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; response to lipopolysaccharide; G-protein signaling, adenylate cyclase activating pathway; regulation of cell proliferation

Disease: Asthma, Nasal Polyps, And Aspirin Intolerance