Rabbit TMEM70 Polyclonal Antibody | anti-TMEM70 antibody

Rabbit Polyclonal to Human TMEM70

Cat. Num. AAA243337

• Gene Names: TMEM70; MC5DN2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: TMEM70; Polyclonal Antibody; Rabbit Polyclonal to Human TMEM70; Anti-TMEM70 Antibody (Internal) IHC-plus; MC5DN2; Transmembrane protein 70; Human TMEM70; anti-TMEM70 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human TMEM70
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 260

• Applicable Applications for anti-TMEM70 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: TMEM70 antibody can be used for detection of TMEM70 by Western blot at 1-2 ug/ml.
• Target Species: Human
• Immunogen Description: A 14 amino acid peptide near the center of human TMEM70.
• Immunogen Type: Synthetic peptide
• Immunogen: TMEM70 antibody was raised against a 14 amino acid peptide near the center of human TMEM70.
• Antigen Modification: Internal
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-TMEM70 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of TMEM70 in rat liver tissue with TMEM70 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot analysis of TMEM70 in human liver tissue lysate with TMEM70 antibody at 1 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 34147498
• NCBI GeneID: 54968
• NCBI Accession #: NP_060336.3
• NCBI GenBank Nucleotide #: NM_017866.5
• UniProt Accession #: Q9BUB7; Q9NWY5; E9PDY9
• Molecular Weight: 11,278 Da
• NCBI Official Full Name: transmembrane protein 70, mitochondrial isoform a
• NCBI Official Synonym Full Names: transmembrane protein 70
• NCBI Official Symbol: TMEM70
• NCBI Official Synonym Symbols: MC5DN2
• NCBI Protein Information: transmembrane protein 70, mitochondrial
• UniProt Protein Name: Transmembrane protein 70, mitochondrial
• Protein Family: Transmembrane protein
• UniProt Gene Name: TMEM70
• UniProt Entry Name: TMM70_HUMAN

NCBI Description

This gene likely encodes a mitochondrial membrane protein. The encoded protein may play a role in biogenesis of mitochondrial ATP synthase. Mutations in this gene have been associated with neonatal mitochondrial encephalocardiomyopathy due to ATP synthase deficiency. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2010]

Uniprot Description

TMEM70: Involved in biogenesis of mitochondrial ATP synthase. Defects in TMEM70 are a cause of mitochondrial complex V deficiency nuclear type 2 (MC5DN2). A mitochondrial disorder with heterogeneous clinical manifestations including dysmorphic features, psychomotor retardation, hypotonia, growth retardation, cardiomyopathy, enlarged liver, hypoplastic kidneys and elevated lactate levels in urine, plasma and cerebrospinal fluid. Belongs to the TMEM70 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Mitochondrial; Membrane protein, integral

Chromosomal Location of Human Ortholog: 8q21.11

Cellular Component: nucleoplasm; mitochondrion; mitochondrial inner membrane

Biological Process: mitochondrial proton-transporting ATP synthase complex assembly

Disease: Mitochondrial Complex V (atp Synthase) Deficiency, Nuclear Type 2