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Immunohistochemistry (IHC) (Anti-CD70 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Rabbit CD27L / CD70 Polyclonal Antibody | anti-CD27L antibody

Rabbit Polyclonal to Human CD27L / CD70

Gene Names
CD70; CD27L; CD27LG; TNFSF7
Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
Applications
Immunohistochemistry
Purity
Immunoaffinity Purified
Synonyms
CD27L / CD70; Polyclonal Antibody; Rabbit Polyclonal to Human CD27L / CD70; Anti-CD27L / CD70 Antibody (N-Terminus) IHC-plus; CD70; CD27LG; Ki-24 antigen; Surface antigen CD70; CD27 ligand; CD27-L; CD70 antigen; CD70 molecule; TNFSF7; Human CD27L; anti-CD27L antibody
Ordering
For Research Use Only!
Host
Rabbit
Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Specificity
Human CD70. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Purity/Purification
Immunoaffinity Purified
Form/Format
PBS, 0.1% sodium azide.
Concentration
0.5 mg/ml (varies by lot)
Sequence Length
193
Applicable Applications for anti-CD27L antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes
IHC-P (10 - 15 ug/ml)
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from N-terminus of human CD70. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (94%); Monkey (88%).
Immunogen Type
Synthetic peptide
Immunogen
CD27L / CD70 antibody was raised against synthetic 17 amino acid peptide from N-terminus of human CD70. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon (94%); Monkey (88%).
Antigen Modification
N-Terminus
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-CD70 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-CD70 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-CD70 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC) (Anti-CD70 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)
Related Product Information for anti-CD27L antibody
CD70, also known as CD27L, is the ligand for CD27. It was first detected on the surface of Reed-Sternberg cells. CD70 is a type II transmembrane protein with an extracellular C-terminal domain. It is homologous to the ligands for the tissue necrosis factor receptor family. CD70 expression in normal tissues has been documented in T and B-lymphocytes, and NK cells in tonsil, gi tract, skin and thymus.
Product Categories/Family for anti-CD27L antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
970
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
23,438 Da
NCBI Official Full Name
CD70 antigen
NCBI Official Synonym Full Names
CD70 molecule
NCBI Official Symbol
CD70
NCBI Official Synonym Symbols
CD27L; CD27LG; TNFSF7
NCBI Protein Information
CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7
UniProt Protein Name
CD70 antigen
UniProt Gene Name
CD70
UniProt Synonym Gene Names
CD27L; CD27LG; TNFSF7; CD27-L
UniProt Entry Name
CD70_HUMAN

NCBI Description

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

Uniprot Description

CD70: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Belongs to the tumor necrosis factor family.

Protein type: Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; protease binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; cell-cell signaling; immune response; signal transduction

Research Articles on CD27L

Similar Products

Product Notes

The CD27L cd70 (Catalog #AAA243002) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit Polyclonal to Human CD27L / CD70 reacts with Gorilla, Human Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity) and may cross-react with other species as described in the data sheet. AAA Biotech's CD27L / CD70 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin). IHC-P (10 - 15 ug/ml). Researchers should empirically determine the suitability of the CD27L cd70 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD27L / CD70, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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