Rabbit SH3BP4 Polyclonal Antibody | anti-SH3BP4 antibody

Rabbit Polyclonal to Human SH3BP4

Cat. Num. AAA242949

• Gene Names: SH3BP4; TTP; BOG25
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: SH3BP4; Polyclonal Antibody; Rabbit Polyclonal to Human SH3BP4; Anti-SH3BP4 Antibody (C-Terminus) IHC-plus; BOG25; EHB10; EH-binding protein 10; SH3-domain binding protein 4; TTP; SH3 domain-binding protein 4; Human SH3BP4; anti-SH3BP4 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Human SH3BP4
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 963

• Applicable Applications for anti-SH3BP4 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml); Usage: SH3BP4 antibody can be used for detection of SH3BP4 by Western blot at 1-2 ug/ml.
• Target Species: Human
• Immunogen Description: An 18 amino acid peptide from near the carboxy terminus of human SH3BP4.
• Immunogen Type: Synthetic peptide
• Immunogen: SH3BP4 antibody was raised against an 18 amino acid peptide from near the carboxy terminus of human SH3BP4.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-SH3BP4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of SH3BP4 in rat lung tissue lysate with SH3BP4 antibody at (A) 1 and (B) 2 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 7657562
• NCBI GeneID: 23677
• NCBI Accession #: NP_055336.1
• NCBI GenBank Nucleotide #: NM_014521.2
• UniProt Accession #: Q9P0V3; O95082; Q309A3; Q53QD0; Q53TD1
• Molecular Weight: 60,337 Da
• NCBI Official Full Name: SH3 domain-binding protein 4
• NCBI Official Synonym Full Names: SH3-domain binding protein 4
• NCBI Official Symbol: SH3BP4
• NCBI Official Synonym Symbols: TTP; BOG25
• NCBI Protein Information: SH3 domain-binding protein 4; EH-binding protein 10; transferrin receptor-trafficking protein
• UniProt Protein Name: SH3 domain-binding protein 4
• Protein Family: SH3 domain-binding protein
• UniProt Gene Name: SH3BP4
• UniProt Synonym Gene Names: BOG25; EHB10; TTP
• UniProt Entry Name: SH3B4_HUMAN

NCBI Description

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

SH3BP4: Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Vesicle

Chromosomal Location of Human Ortholog: 2q37.1-q37.2

Cellular Component: clathrin-coated vesicle; cytoplasm; coated pit; nucleus

Molecular Function: identical protein binding; protein binding; Ras GTPase binding; GDP-dissociation inhibitor activity

Biological Process: negative regulation of cell proliferation; negative regulation of TOR signaling pathway; regulation of catalytic activity; endocytosis; negative regulation of cell growth; positive regulation of autophagy; amino acid import