Rabbit SF1 Polyclonal Antibody | anti-SF1 antibody
Anti-SF1 Antibody (aa45-98)
Predicted: Mouse, Rat
Predicted: Mouse, Rat
IHC-P: 1:200-1:100
WB: 1:500-1:1000
Aliquot and store at -20 degree C for long term.
Avoid freeze-thaw cycles.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Uniprot Description
Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor.