Rabbit anti-Human PZP Polyclonal Antibody | anti-PZP antibody

Anti-PZP Antibody

Cat. Num. AAA2401357

• Gene Names: PZP; CPAMD6
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Caprylic acid and ammonium sulfate precipitation
• Synonyms: PZP; Polyclonal Antibody; Anti-PZP Antibody; Rabbit Polyclonal (IgG) to Mouse PZP; CPAMD6; Pregnancy-zone protein; Pregnancy zone protein; anti-PZP antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Human PZP
• Purity/Purification: Caprylic acid and ammonium sulfate precipitation
• Form/Format: PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
• Sequence Length: 1482

• Applicable Applications for anti-PZP antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: IHC-P: 10 ug/ml
• Immunogen: Recombinant human Pregnancy zone protein encoding amino acids 472-821.
• Conjugation: Unconjugated
• Preparation and Storage: Short term: 4 degree C; Long term: -20 degree C.; Avoid freeze-thaw cycles.

Immunohistochemistry (IHC)

(Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.)

Immunohistochemistry (WB)

(Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE). This image was taken for the unconjugated form of this product. Other forms have not been tested.)

Related Product Information for anti-PZP antibody

Is able to inhibit all four classes of protein ases by a unique'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for differentproteinases. When a protein ase cleaves the bait region, a conformationalchange is induced in the protein which traps the protein ase. the entrapped enzyme remains active against low molecular weight substrates(activity against high molecular weight substrates is greatly reduced).

NCBI and Uniprot Product Information

• NCBI GI #: 162809334
• NCBI GeneID: 5858
• NCBI Accession #: NP_002855.2
• NCBI GenBank Nucleotide #: NM_002864.2
• UniProt Accession #: P20742; Q15273; Q2NKL2; Q7M4N7; A6ND27
• Molecular Weight: 140,368 Da
• NCBI Official Full Name: pregnancy zone protein
• NCBI Official Synonym Full Names: PZP, alpha-2-macroglobulin like
• NCBI Official Symbol: PZP
• NCBI Official Synonym Symbols: CPAMD6
• NCBI Protein Information: pregnancy zone protein
• UniProt Protein Name: Pregnancy zone protein
• Protein Family: Pregnancy zone protein
• UniProt Gene Name: PZP
• UniProt Synonym Gene Names: CPAMD6

NCBI Description

The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients. [provided by RefSeq, Dec 2016]

Uniprot Description

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.