Mouse anti-Human NPPB/BNP Monoclonal Antibody | anti-NPPB/BNP antibody

Anti-NPPB/BNP Antibody (clone 57H3)

Cat. Num. AAA2400742

• Gene Names: NPPB; BNP
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry, ELISA, Western Blot
• Purity: Protein A purified
• Synonyms: NPPB/BNP; Monoclonal Antibody; Anti-NPPB/BNP Antibody (clone 57H3); Mouse Monoclonal [clone 43B12] (IgG2a) to Human NPPB/BNP; NPPB; BNP; Natriuretic peptides B; Natriuretic peptide B; Natriuretic protein; Brain type natriuretic peptide; anti-NPPB/BNP antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a
• Clone Number: 57H3
• Specificity: Human BNP and proBNP
• Purity/Purification: Protein A purified
• Form/Format: PBS, pH 7.4, 0.1 % sodium azide.
• Sequence Length: 134

• Applicable Applications for anti-NPPB/BNP antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Sandwich ELISA (EIA), Western Blot (WB)
• Application Notes: IHC-P: 10 ug/ml
• Immunogen: Human synthetic BNP (whole molecule) or synthetic BNP peptide 11FGRKMDRISSSS22 (for MAbs 24C5 and 26E2) conjugated with carrier protein. Percent identity by BLAST analysis: Human, Gibbon (100%); Marmoset (83%).
• Conjugation: Unconjugated
• Preparation and Storage: Store at 4 degree C, avoid freezing.

Immunohistochemistry (IHC)

(Anti-BNP antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.)

Related Product Information for anti-NPPB/BNP antibody

NPPB/BNP is a member of the natriuretic peptide family and encodes asecreted protein which functions as a cardiac hormone. the protein undergoes two cleavage events, one within the cell and a second aftersecretion into the blood. the protein's biological actions includenatriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. Ahigh concentration of this protein in the bloodstream is indicative ofheart failure.

NCBI and Uniprot Product Information

• NCBI GI #: 4505433
• NCBI GeneID: 4879
• NCBI Accession #: NP_002512.1
• NCBI GenBank Nucleotide #: NM_002521.2
• UniProt Accession #: P16860; Q6FGY0; Q9P2Q7; B0ZBE9
• Molecular Weight: 14,726 Da
• NCBI Official Full Name: natriuretic peptides B preproprotein
• NCBI Official Synonym Full Names: natriuretic peptide B
• NCBI Official Symbol: NPPB
• NCBI Official Synonym Symbols: BNP
• NCBI Protein Information: natriuretic peptides B
• UniProt Protein Name: Natriuretic peptides B
• UniProt Gene Name: NPPB
• UniProt Synonym Gene Names: BNP(1-32); BNP-32

NCBI Description

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

Uniprot Description

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.