Rabbit PAWR/PAR4 Polyclonal Antibody | anti-PAWR/PAR4 antibody

Anti-PAWR/PAR4 Antibody (aa291-340)

Cat. Num. AAA2400732

• Gene Names: PAWR; PAR4; Par-4
• Reactivity: Human; Predicted: Mouse, Rat
• Applications: ELISA, Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: PAWR/PAR4; Polyclonal Antibody; Anti-PAWR/PAR4 Antibody (aa291-340); Rabbit Polyclonal to Human PAWR/PAR4; PAWR; PAR4; WT1-interacting protein; Par-4; Transcriptional repressor PAR4; anti-PAWR/PAR4 antibody

• Host: Rabbit
• Reactivity: Human; Predicted: Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Prostate Apoptosis Response protein-4 Antibody detects endogenous levels of total Prostate Apoptosis Response protein-4 protein.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
• Sequence Length: 340

• Applicable Applications for anti-PAWR/PAR4 antibody: ELISA (EIA), Immunohistochemistry (IHC) Paraffin, Western Blot (WB)
• Application Notes: ELISA: 1:10000; IHC-P: 1:50; WB: 1:500-1:1000
• Immunogen: Synthetic peptide from human Prostate Apoptosis Response protein-4 (aa291-340).
• Conjugation: Unconjugated
• Epitope: aa291-340
• Preparation and Storage: Store at -20 degree C for up to one year.

Immunohistochemistry (IHC)

(Anti-PAWR/PAR4 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Immunohistochemistry (WB)

(Anti-PAWR/PAR4 antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.)

Western Blot (WB)

(Western blot of extracts from NIH-3T3 cells, using Prostate Apoptosis Response protein-4 Antibody. The lane on the right is treated with the synthesized peptide.)

Related Product Information for anti-PAWR/PAR4 antibody

Pro-apoptopic protein capable of selectively inducing apoptosis incancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis incertain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. inhibits the transcriptional activation and augments the transcriptionalrepression mediated by WT1.

NCBI and Uniprot Product Information

• NCBI GI #: 55769533
• NCBI GeneID: 5074
• NCBI Accession #: NP_002574.2
• NCBI GenBank Nucleotide #: NM_002583.3
• UniProt Accession #: Q96IZ0; O75796; Q6FHY9; Q8N700
• Molecular Weight: 36,568 Da
• NCBI Official Full Name: PRKC apoptosis WT1 regulator protein isoform 1
• NCBI Official Synonym Full Names: pro-apoptotic WT1 regulator
• NCBI Official Symbol: PAWR
• NCBI Official Synonym Symbols: PAR4; Par-4
• NCBI Protein Information: PRKC apoptosis WT1 regulator protein
• UniProt Protein Name: PRKC apoptosis WT1 regulator protein
• UniProt Gene Name: PAWR
• UniProt Synonym Gene Names: PAR4; Par-4

NCBI Description

This gene encodes a tumor suppressor protein that selectively induces apoptosis in cancer cells through intracellular and extracellular mechanisms. The intracellular mechanism involves the inhibition of pro-survival pathways and the activation of Fas-mediated apoptosis, while the extracellular mechanism involves the binding of a secreted form of this protein to glucose regulated protein 78 (GRP78) on the cell surface, which leads to activation of the extrinsic apoptotic pathway. This gene is located on the unstable human chromosomal 12q21 region and is often deleted or mutated different tumors. The encoded protein also plays an important role in the progression of age-related diseases. [provided by RefSeq, Aug 2017]

Uniprot Description

Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.