Immunohistochemistry (IHC)
(Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit LCX / TET1 Polyclonal Antibody | anti-LCX / TET1 antibody
Anti-LCX / TET1 Antibody (C-Terminus) IHC-plus
IHC-P (10 ug/ml)
WB (1 - 2 ug/ml)
Short term: 4 degree C
Avoid repeat freeze-thaw cycles
Immunohistochemistry (IHC)
(Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Adrenal: Formalin-Fixed, Paraffin-Embedded (FFPE))
NCBI and Uniprot Product Information
NCBI Description
DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
Uniprot Description
TET1: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5- hydroxymethylcytosine (5hmC). Might initiate a process leading to cytosine demethylation through deamination into 5- hydroxymethyluracil (5hmU) and subsequent replacement by unmethylated cytosine by the base excision repair system. Methylation at the C5 position of cytosine bases is an epigenetic modification of the mammalian genome which plays an important role in transcriptional regulation. Preferentially binds to CpG-rich sequences at promoters of both transcriptionally active and polycomb-repressed genes. By controlling the levels of 5mC and 5hmC at gene promoters, it may regulate the gene expression silencing induced by cytosine methylation. May have a dual function by also repressing the expression of a subset of genes through recruitment of transcriptional repressors to promoters. Involved in the balance between pluripotency and lineage commitment of cells it plays a role in embryonic stem cells maintenance and inner cell mass cell specification. A chromosomal aberration involving TET1 may be a cause of acute leukemias. Translocation t(10;11)(q22;q23) with MLL. This is a rare chromosomal translocation 5' MLL-TET1 3'. Belongs to the TET family.
Protein type: DNA-binding; EC 1.14.11.n2; Oxidoreductase
Chromosomal Location of Human Ortholog: 10q21
Cellular Component: nucleus
Molecular Function: iron ion binding; structure-specific DNA binding; zinc ion binding
Biological Process: chromatin modification; gene expression; inner cell mass cell differentiation; positive regulation of cell proliferation; positive regulation of histone methylation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid O-linked glycosylation; regulation of gene expression, epigenetic; stem cell maintenance; transcription, DNA-dependent
Research Articles on LCX / TET1
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Product Notes
The LCX / TET1 tet1 (Catalog #AAA2400130) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-LCX / TET1 Antibody (C-Terminus) IHC-plus reacts with Mouse, Rat, Human and may cross-react with other species as described in the data sheet. AAA Biotech's LCX / TET1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Immunofluorescence (IF), Western Blot (WB), ELISA (EIA). IF (20 ug/ml) IHC-P (10 ug/ml) WB (1 - 2 ug/ml). Researchers should empirically determine the suitability of the LCX / TET1 tet1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LCX / TET1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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