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IFN BETA 1A Active Protein | IFNB1 active protein

RECOMBINANT HUMAN INTERFERON BETA 1 ALPHA

Gene Names
IFNB1; IFB; IFF; IFNB
Applications
Functional Assay
Purity
>98.0% as determined by HPLC and SDS-PAGE.
Synonyms
IFN BETA 1A; RECOMBINANT HUMAN INTERFERON BETA 1 ALPHA; IFNB1 active protein
Ordering
For Research Use Only!
Purity/Purification
>98.0% as determined by HPLC and SDS-PAGE.
Form/Format
Recombinant protein - lyophilised
Concentration
Total protein concentration 0.1 mg/ml after reconstitution (varies by lot)
Sequence Length
187
Applicable Applications for IFNB1 active protein
Functional Assays (FN)
Reconstitution
Reconstitute with 50ul of distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.
Perservative Stabilisers
Buffer Solution
0.01M Sodium Acetate
Activity
270 x 106 IU/mg, as determined in a viral resistance assay
Target Species
Human
Preparation and Storage
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 12 months from date of reconstitution
Related Product Information for IFNB1 active protein
Recombinant human interferon beta 1a is a CHO cell derived recombinant protein corresponding to single, glycosylated polypeptide chain containing 166 amino acid. Interferon beta 1a is a 22 kDa cytokine and member of the type 1 interferon family. Interferons exhibit anti-viral and anti proliferative effects and also influence the immune response. Effects on the immune system mediated by interferons may be mediated by increased expression of major histocompatability complex (MHC) antigens. Interferon beta a has been shown to exhibit therapeutic efficacy against viral infections, different types of cancer and multiple sclerosis (Borden et al. 2007).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
22,294 Da
NCBI Official Full Name
interferon beta
NCBI Official Synonym Full Names
interferon, beta 1, fibroblast
NCBI Official Symbol
IFNB1
NCBI Official Synonym Symbols
IFB; IFF; IFNB
NCBI Protein Information
interferon beta; IFN-beta; fibroblast interferon
UniProt Protein Name
Interferon beta
Protein Family
UniProt Gene Name
IFNB1
UniProt Synonym Gene Names
IFB; IFNB; IFN-beta
UniProt Entry Name
IFNB_HUMAN

Uniprot Description

IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 9p21

Cellular Component: extracellular space; extracellular region

Molecular Function: interferon-alpha/beta receptor binding; cytokine activity

Biological Process: B cell proliferation; adaptive immune response; response to virus; cytokine and chemokine mediated signaling pathway; regulation of MHC class I biosynthetic process; natural killer cell activation; negative regulation of T cell differentiation; humoral immune response; T cell activation during immune response; response to exogenous dsRNA; cell surface receptor linked signal transduction; negative regulation of viral genome replication; B cell differentiation; positive regulation of innate immune response; defense response to bacterium; natural killer cell activation during immune response; innate immune response; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; defense response to virus; B cell activation during immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein

Research Articles on IFNB1

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Product Notes

The IFNB1 ifnb1 (Catalog #AAA232524) is an Active Protein and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's IFN BETA 1A can be used in a range of immunoassay formats including, but not limited to, Functional Assays (FN). Researchers should empirically determine the suitability of the IFNB1 ifnb1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "IFN BETA 1A, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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