Sheep CALRETININ Polyclonal Antibody | anti-CALB2 antibody

SHEEP ANTI GUINEA PIG CALRETININ

Cat. Num. AAA223868

• Gene Names: CALB2; CR; CAL2; CAB29
• Reactivity: Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence), Rat
• Applications: Immunohistochemistry, Western Blot
• Synonyms: CALRETININ; Polyclonal Antibody; SHEEP ANTI GUINEA PIG CALRETININ; anti-CALB2 antibody

• Host: Sheep
• Reactivity: Human (Expected from Sequence), Mouse (Expected from Sequence), Primate (Expected from Sequence), Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: This item recognises calretinin, a 29kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination. ; ; Calretinin has also been shown as a sensitive and specific marker for mast cells.
• Form/Format: Purified; Purified IgG - liquid
• Sequence Length: 271

• Applicable Applications for anti-CALB2 antibody: Immunohistology Frozen, Western Blot (WB)
• Application Notes: Western Blot: This item detects a band of approximately 29kDa in rat cerebellum.; Immunohistology - Frozen: Maximum Dilution: 1/500; Western Blotting: Maximum Dilution: 1/1000
• Perservative Stabilisers: 0.09% Sodium Azide (NaN3)
• Immunogen: Purified guinea pig calretinin; Buffer Solution
• Antiserum Preparation: Antisera to Calretinin were raised by repeated immunisations of sheep with highly purified antigen. Purified IgG was prepared from whole serum by Protein A chromatography.
• Target Species: Guinea Pig
• Preparation and Storage: Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 18 months from date of despatch.

Related Product Information for anti-CALB2 antibody

MBS223868 recognises calretinin, a 29kDa calcium binding protein found mostly in the central nervous system and retina. It is a cytoplasmic protein involved in the regulation of calcium concentration, which is important in the regulation of a large variety of neuronal functions, including neurotransmitter release, ionic channel permeability, enzyme activity, and gene transcription. Mice deficient in calretinin show impairment in motor coordination. Calretinin has also been shown as a sensitive and specific marker for mast cells.

NCBI and Uniprot Product Information

• NCBI GI #: 153946409
• NCBI GeneID: 794
• NCBI Accession #: NP_001731.2
• NCBI GenBank Nucleotide #: NM_001740.4
• Molecular Weight: 31,540 Da
• NCBI Official Full Name: calretinin isoform 1
• NCBI Official Synonym Full Names: calbindin 2
• NCBI Official Symbol: CALB2
• NCBI Official Synonym Symbols: CR; CAL2; CAB29
• NCBI Protein Information: calretinin; 29 kDa calbindin; calbindin 2, (29kD, calretinin); calbindin D29K
• UniProt Protein Name: Calretinin
• Protein Family: Calretinin
• UniProt Gene Name: CALB2
• UniProt Synonym Gene Names: CAB29; CR
• UniProt Entry Name: CALB2_HUMAN

NCBI Description

This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Uniprot Description

CALB2: Calretinin is a calcium-binding protein which is abundant in auditory neurons. Belongs to the calbindin family.

Protein type: Calcium-binding

Chromosomal Location of Human Ortholog: 16q22.2

Cellular Component: cytoplasm; gap junction; nucleus

Molecular Function: calcium ion binding

Biological Process: cytosolic calcium ion homeostasis