Rabbit CCL17 Polyclonal Antibody | anti-CCL17 antibody

RABBIT ANTI HUMAN CCL17

Cat. Num. AAA223514

• Gene Names: CCL17; TARC; ABCD-2; SCYA17; A-152E5.3
• Applications: ELISA, Functional Assay, Western Blot
• Synonyms: CCL17; Polyclonal Antibody; RABBIT ANTI HUMAN CCL17; anti-CCL17 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Isotype: IgG
• Form/Format: Purified; Purified IgG - lyophilised
• Concentration: IgG concentration 1.0mg/ml after reconstitution (varies by lot)
• Sequence Length: 94

• Applicable Applications for anti-CCL17 antibody: ELISA (EIA), Functional Assays (FN), Western Blot (WB)
• Application Notes: ELISA: Minimum Dilution: 0.5; Maximum Dilution: 2.0ug/ml;; Functional Assays: Minimum Dilution: 20; Maximum Dilution: 30ug/ml;; Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.2ug/ml
• Reconstitution: Reconstitute with 0.1ml distilled water Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For long term storage the addition of 0.09% sodium azide is recommended. N.B. For functional studies do not add sodium azide
• Immunogen: Recombinant human CCL17; Buffer Solution
• Antiserum Preparation: Antiserum to human CCL17 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG was prepared from whole serum by affinity chromatography.
• Target Species: Human
• Preparation and Storage: Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.; Shelf Life: 12 months from date of reconstitution.

Related Product Information for anti-CCL17 antibody

Rabbit anti Human CCL17 antibody specifically recognizes human CCL17, otherwise known as TARC (thymus and activation-regulated chemokine), a member of the intercrine beta (chemokine CC) family, predominantly produced by thymic dendritic cells, which specifically acts as a chemotactic factor for T cells, and signals through binding to the CCR4 receptor.

NCBI and Uniprot Product Information

• NCBI GI #: 4506829
• NCBI GeneID: 6361
• NCBI Accession #: NP_002978.1
• NCBI GenBank Nucleotide #: NM_002987.2
• UniProt Accession #: Q92583; Q2M287; A0N0Q9
• Molecular Weight: 10,507 Da
• NCBI Official Full Name: C-C motif chemokine 17
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 17
• NCBI Official Symbol: CCL17
• NCBI Official Synonym Symbols: TARC; ABCD-2; SCYA17; A-152E5.3
• NCBI Protein Information: C-C motif chemokine 17; CC chemokine TARC; T cell-directed CC chemokine; small inducible cytokine subfamily A (Cys-Cys), member 17; small-inducible cytokine A17; thymus and activation-regulated chemokine
• UniProt Protein Name: C-C motif chemokine 17
• Protein Family: C-C motif chemokine
• UniProt Gene Name: CCL17
• UniProt Synonym Gene Names: SCYA17; TARC
• UniProt Entry Name: CCL17_HUMAN

NCBI Description

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL17: Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR4 chemokine receptor binding; chemokine activity; receptor binding

Biological Process: G-protein coupled receptor protein signaling pathway; cell-cell signaling; multicellular organismal development; immune response; inflammatory response; chemotaxis; negative regulation of myoblast differentiation