Goat RXR ALPHA Polyclonal Antibody | anti-RXR ALPHA antibody
GOAT ANTI RXR ALPHA
RXRs play important roles in multiple signalling pathways, including cell growth, differentiation, homeostasis, metabolism, and development.
This item does not cross-react with either RXR beta or gamma.
Purified IgG - liquid
ELISA: Minimum Dilution: 1/15000; Maximum Dilution: 1/20000
Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 3ug/ml
0.5% Bovine Serum Albumin
Buffer Solution
Shelf Life: 18 months from date of despatch.
NCBI and Uniprot Product Information
NCBI Description
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
RXRA: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. Homodimer. Heterodimer with RARA; required for ligand- dependent retinoic acid receptor transcriptional activity. Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity. Also heterodimerizes with PPARG. Interacts with NCOA3 and NCOA6 coactivators. Interacts with FAM120B. Interacts with PELP1, SENP6, SFPQ, DNTTIP2 and RNF8. Interacts (via the DNA binding domain) with HCV core protein; the interaction enhances the transcriptional activities of the RXRA/RARA and the RXRA/PPARA heterodimers. Interacts with PRMT2. Interacts with ASXL1 and NCOA1. Highly expressed in liver, also found in lung, kidney and heart. Belongs to the nuclear hormone receptor family. NR2 subfamily.
Protein type: Nuclear receptor; DNA-binding; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.3
Cellular Component: nucleoplasm; nuclear chromatin; nucleus; receptor complex
Molecular Function: ligand-dependent nuclear receptor activity; zinc ion binding; chromatin DNA binding; transcription coactivator activity; protein binding; enzyme binding; DNA binding; retinoid-X receptor activity; vitamin D receptor binding; sequence-specific DNA binding; protein heterodimerization activity; steroid hormone receptor activity; retinoic acid receptor activity; transcription factor activity
Biological Process: retinoic acid receptor signaling pathway; cholesterol metabolic process; transcription initiation from RNA polymerase II promoter; camera-type eye development; vitamin metabolic process; response to retinoic acid; in utero embryonic development; ventricular cardiac muscle cell differentiation; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of translational initiation by iron; protein homotetramerization; virus-host interaction; ventricular cardiac muscle morphogenesis; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; transmembrane transport; embryo implantation; maternal placenta development
Research Articles on RXR ALPHA
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Product Notes
The RXR ALPHA rxra (Catalog #AAA221408) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The GOAT ANTI RXR ALPHA reacts with Mouse (Expected from Sequence), Rat (Expected from Sequence) and may cross-react with other species as described in the data sheet. AAA Biotech's RXR ALPHA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). Western Blot: This item detects a band of approximately 55kDa in human epidermoid carcinoma A431 lysates. A minimum incubation time of 1 hour is recommended with this antibody. ELISA: Minimum Dilution: 1/15000; Maximum Dilution: 1/20000 Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 3ug/ml. Researchers should empirically determine the suitability of the RXR ALPHA rxra for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "RXR ALPHA, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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