Rat CD279 Monoclonal Antibody | anti-CD279 antibody
RAT ANTI MOUSE CD279
Gene Names
Pdcd1; PD-1; Pdc1; Ly101
Applications
Flow Cytometry, Functional Assay
Synonyms
CD279; Monoclonal Antibody; RAT ANTI MOUSE CD279; anti-CD279 antibody
Host
Rat
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
RMP1-30
Form/Format
Purified
Purified IgG - liquid
Purified IgG - liquid
Concentration
IgG concentration 1 mg/ml (varies by lot)
Sequence Length
288
Applicable Applications for anti-CD279 antibody
Flow cytometry (FC/FACS)
Application Notes
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200
Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200
Perservative Stabilisers
0.09% Sodium Azide (NaN3)
Preparation
Preparation
Immunogen
PD-1 transferred BHK cells
Fusion Partners
Fusion Partners
Target Species
Mouse
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Shelf Life: 18 months from date of despatch.
Related Product Information for anti-CD279 antibody
Rat anti Mouse CD279 antibody, clone RMP1-30 recognizes mouse CD279, a 55kD cell surface protein which is a member of the CD28/CTLA-4 family, otherwise known as Programmed Death-1 (PD-1). CD279 is expressed predominantly on activated T- and B- lymphocytes and on a subset of thymocytes. Studies suggest that CD279, an immunoinhibitory receptor, plays a critical role in peripheral tolerance induction and prevention of autoimmune disease. Two members of the B7 family, B7-H1 (PD-L1) and B7-DC (PD-L2), have been identified as the ligands for CD279. Antibodies produced by clone RMP1-30 do not block the binding of both B7-H1-Ig and B7-DC-Ig fusion proteins to PD-1 transfected BHK cells.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
31,842 Da
NCBI Official Full Name
programmed cell death protein 1
NCBI Official Synonym Full Names
programmed cell death 1
NCBI Official Symbol
Pdcd1
NCBI Official Synonym Symbols
PD-1; Pdc1; Ly101
NCBI Protein Information
programmed cell death protein 1; mPD-1; protein PD-1
UniProt Protein Name
Programmed cell death protein 1
UniProt Gene Name
Pdcd1
UniProt Synonym Gene Names
Pd1; Protein PD-1; mPD-1
UniProt Entry Name
PDCD1_MOUSE
Uniprot Description
PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.
Protein type: Apoptosis; Membrane protein, integral
Cellular Component: membrane; integral to membrane; plasma membrane; external side of plasma membrane
Molecular Function: protein binding
Biological Process: positive regulation of apoptosis; immune system process; apoptosis; negative regulation of tolerance induction; negative regulation of apoptosis
Research Articles on CD279
Similar Products
Product Notes
The CD279 pdcd1 (Catalog #AAA214321) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CD279 can be used in a range of immunoassay formats including, but not limited to, Flow cytometry (FC/FACS). Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul. Flow Cytometry: Minimum Dilution: 1/100; Maximum Dilution: 1/200. Researchers should empirically determine the suitability of the CD279 pdcd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD279, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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