Insulin Like Growth Factor 2 Recombinant Protein | IGF2 recombinant protein

Recombinant Insulin Like Growth Factor 2 (IGF2)

Cat. Num. AAA2122520

• Gene Names: Igf2; Mpr; M6pr; Peg2; Igf-2; Igf-II; AL033362
• Applications: SDS-Page, Western Blot
• Purity: >97%
• Synonyms: Insulin Like Growth Factor 2; Recombinant Insulin Like Growth Factor 2 (IGF2); INSIGF; IGF-II; Somatomedin A; Preptin; Insulin-like growth factor II Ala-25 Del; IGF2 recombinant protein

• Host: E Coli
• Purity/Purification: >97%
• Form/Format: Freeze-dried powder; PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Sequence Length: 191

• Applicable Applications for IGF2 recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Source: Prokaryotic expression
• Species: Mouse
• Tag: N-terminal His Tag
• Subcellular Location: Secreted
• Reconstitution: Reconstitute in PBS or others.
• Preparation and Storage: Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.; Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for IGF2 recombinant protein

Tumor immunity; Endocrinology

NCBI and Uniprot Product Information

• NCBI GI #: 298231180
• NCBI GeneID: 16002
• NCBI Accession #: NP_034644.2
• NCBI GenBank Nucleotide #: NP_034644.2
• UniProt Accession #: p09535; P09535
• NCBI Official Full Name: insulin-like growth factor II isoform 1
• NCBI Official Synonym Full Names: insulin-like growth factor 2
• NCBI Official Symbol: Igf2
• NCBI Official Synonym Symbols: Mpr; M6pr; Peg2; Igf-2; Igf-II; AL033362
• NCBI Protein Information: insulin-like growth factor II
• UniProt Protein Name: Insulin-like growth factor II
• Protein Family: Insulin-like growth factor
• UniProt Gene Name: Igf2
• UniProt Synonym Gene Names: Igf-2
• UniProt Entry Name: IGF2_MOUSE

NCBI Description

This gene encodes a member of the insulin-like growth factor (IGF) family of proteins that promote growth and development during fetal and postnatal life. It is an imprinted gene that is expressed only from the paternal allele. The encoded protein undergoes proteolytic processing to generate a mature peptide. The transgenic overexpression of this gene in mice results in prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities. Mice lacking the encoded protein exhibit growth deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Oct 2015]

Uniprot Description

Function: The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Ref.7 Ref.8Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. Ref.7 Ref.8

Subcellular location: Secreted.

Developmental stage: Low levels of expression during myoblast proliferation. Levels rise rapidly during myoblast differentiation and then decrease.

Sequence similarities: Belongs to the insulin family.