Mouse anti-Mouse Apolipoprotein C1 (APOC1) Monoclonal Antibody | anti-APOC1 antibody

APC-Linked Monoclonal Antibody to Apolipoprotein C1 (APOC1)

Cat. Num. AAA2106611

• Gene Names: Apoc1; apo-CI; apoC-I; Apo-CIB; ApoC-IB
• Reactivity: Mouse
• Applications: Western Blot, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation
• Purity: Antigen-specific affinity chromatography followed by Protein A affinity chromatography
• Synonyms: Apolipoprotein C1 (APOC1); Monoclonal Antibody; APC-Linked Monoclonal Antibody to Apolipoprotein C1 (APOC1); anti-APOC1 antibody

• Host: Mouse
• Reactivity: Mouse
• Clonality: Monoclonal
• Specificity: The antibody is a mouse monoclonal antibody raised against APOC1. It has been selected for its ability to recognize APOC1 in immunohistochemical staining and western blotting.
• Purity/Purification: Antigen-specific affinity chromatography followed by Protein A affinity chromatography
• Form/Format: Liquid
• Concentration: >=100ug/ml (varies by lot)
• Sequence: Gly32~Ser88
• Sequence Length: 88

• Applicable Applications for anti-APOC1 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP)
• Conjugation: APC
• Cross Reactivity: Mouse
• Preparation and Storage: Store at 4 degree C for frequent use. Aliquot and store at -20 degree C for 12 months.; Avoid repeated freeze/thaw cycles.; ; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Product Categories/Family for anti-APOC1 antibody

Metabolic pathway

NCBI and Uniprot Product Information

• NCBI GI #: 158517825
• NCBI GeneID: 11812
• NCBI Accession #: NP_001103479.1
• NCBI GenBank Nucleotide #: NM_001110009.2
• UniProt Accession #: P34928
• NCBI Official Full Name: apolipoprotein C-I
• NCBI Official Synonym Full Names: apolipoprotein C-I
• NCBI Official Symbol: Apoc1
• NCBI Official Synonym Symbols: apo-CI; apoC-I; Apo-CIB; ApoC-IB
• NCBI Protein Information: apolipoprotein C-I
• UniProt Protein Name: Apolipoprotein C-I
• Protein Family: Apolipoprotein
• UniProt Gene Name: Apoc1
• UniProt Synonym Gene Names: Apoc1b; Apo-CIB; ApoC-IB; Apo-CIB'; ApoC-IB'
• UniProt Entry Name: APOC1_MOUSE

NCBI Description

This gene encodes a precursor plasma protein that is cleaved to yield a signal peptide and two alternatively processed mature peptides. The encoded protein, which is a component of chylomicrons, very low density lipoproteins and high density lipoproteins, transports lipids from the intestines to other locations in the body. This protein binds to free fatty acids preventing their uptake by cells. This protein is a cofactor for lecithin cholesterol acyltransferase, an enzyme that catalyzes the conversion of free cholesterol to cholesteryl esters. The encoded protein inhibits the activity of the cholesteryl ester transfer protein which promotes the exchange of neutral lipids between lipoproteins. In humans this gene is associated with risk of coronary artery disease and age-associated memory impairment. Mice lacking this gene demonstrate impaired memory. This gene is clustered with three other apolipoprotein genes on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Uniprot Description

Function: Appears to modulate the interaction of APOE with beta-migrating VLDL and inhibit binding of beta-VLDL to the LDL receptor-related protein. Binds free fatty acids and reduces their intracellular esterification. Ref.4

Subcellular location: Secreted.

Tissue specificity: Secreted in plasma.

Sequence similarities: Belongs to the apolipoprotein C1 family.