Natriuretic Peptide Precursor B (NPPB) Recombinant Protein | NPPB recombinant protein

Recombinant Natriuretic Peptide Precursor B (NPPB)

Cat. Num. AAA2097529

• Gene Names: NPPB; BNP
• Reactivity: Human
• Applications: SDS-Page, Western Blot
• Purity: > 97%
• Synonyms: Natriuretic Peptide Precursor B (NPPB); Recombinant Natriuretic Peptide Precursor B (NPPB); NPPB recombinant protein

• Reactivity: Human
• Purity/Purification: > 97%
• Form/Format: Freeze-dried powder
• Sequence Length: 134

• Applicable Applications for NPPB recombinant protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Expression System: Prokaryotic expression
• Tag: N-terminal His and GST Tag
• Buffer Formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Fragment: His27~His134
• Subcellular Location: Secreted
• Isoelectric Point: 10.1

Sequence Information

SDS-Page

Testing Data

NCBI and Uniprot Product Information

• NCBI GI #: 4505433
• NCBI GeneID: 4879
• NCBI Accession #: NP_002512.1
• NCBI GenBank Nucleotide #: NM_002521.2
• UniProt Accession #: P16860; Q6FGY0; Q9P2Q7; B0ZBE9
• Molecular Weight: Predicted Molecular Weight: 41.9kDa; Accurate Molecular Weight: 44kDa
• NCBI Official Full Name: natriuretic peptides B preproprotein
• NCBI Official Synonym Full Names: natriuretic peptide B
• NCBI Official Symbol: NPPB
• NCBI Official Synonym Symbols: BNP
• NCBI Protein Information: natriuretic peptides B
• UniProt Protein Name: Natriuretic peptides B
• Protein Family: Natriuretic peptides
• UniProt Gene Name: NPPB
• UniProt Synonym Gene Names: BNP(1-32); BNP-32

NCBI Description

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

Uniprot Description

NPPB: Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3. Belongs to the natriuretic peptide family.

Protein type: Hormone; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1p36.22

Cellular Component: extracellular region; extracellular space; nucleus; perinuclear region of cytoplasm; protein complex

Molecular Function: diuretic hormone activity; hormone activity; peptide hormone receptor binding; protein binding; receptor binding

Biological Process: body fluid secretion; cell surface receptor signaling pathway; cGMP biosynthetic process; inflammatory response; negative regulation of angiogenesis; negative regulation of cell growth; negative regulation of smooth muscle cell proliferation; negative regulation of systemic arterial blood pressure; protein folding; receptor guanylyl cyclase signaling pathway; regulation of blood pressure; regulation of vascular permeability; response to calcium ion; response to drug; response to hypoxia; response to lipopolysaccharide; response to organic cyclic compound; response to peptide hormone