Rabbit anti-Human Toll Like Receptor Adaptor Molecule 1 (TICAM1) Polyclonal Antibody | anti-TICAM1 antibody
Biotin-Linked Polyclonal Antibody to Toll Like Receptor Adaptor Molecule 1 (TICAM1)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes an adaptor protein containing a Toll/interleukin-1 receptor (TIR) homology domain, which is an intracellular signaling domain that mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. This protein is involved in native immunity against invading pathogens. It specifically interacts with toll-like receptor 3, but not with other TLRs, and this association mediates dsRNA induction of interferon-beta through activation of nuclear factor kappa-B, during an antiviral immune response. [provided by RefSeq, Jan 2012]
Uniprot Description
TICAM1: an adaptor protein involved in innate immunity against invading pathogens. Associates with TLR3 and TLR4 (through TICAM2) to mediate NF-kappa-B and interferon-regulatory factor (IRF) activation, and to induce apoptosis. Ligand binding to these receptors results in TICAM1 recruitment through its TIR domain. Distinct protein-interaction motifs allow recruitment of the effector proteins TBK1, TRAF6 and RIPK1, which in turn, lead to the activation of transcription factors IRF3 and IRF7, NF-kappa-B and FADD respectively. Interacts with the TIR domain of TLR3. Interacts with AZI2, TBK1, IRF3 and IRF7. Interacts with TICAM2 in TLR4 recruitment. Interaction with PIAS4 inhibits the TICAM1-induced NF-kappa-B, IRF and IFNB1 activation. Interacts with IKBKB and IKBKE. Interaction with SARM1 blocks TICAM1-dependent transcription factor activation. Interacts with TRAF3. Interacts with TRAFD1.
Protein type: Adaptor/scaffold; Apoptosis
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component: autophagic vacuole; cytosol; endosome membrane
Molecular Function: protein binding; protein kinase binding; signal transducer activity
Biological Process: defense response to virus; I-kappaB kinase/NF-kappaB signaling; inflammatory response; innate immune response; lipopolysaccharide-mediated signaling pathway; macrophage activation involved in immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of autophagy; positive regulation of B cell proliferation; positive regulation of chemokine biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interferon-beta biosynthetic process; positive regulation of interleukin-6 production; positive regulation of natural killer cell activation; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of tumor necrosis factor production; regulation of protein homodimerization activity; response to exogenous dsRNA
Disease: Herpes Simplex Encephalitis, Susceptibility To, 4
Research Articles on TICAM1
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Product Notes
The TICAM1 ticam1 (Catalog #AAA2096327) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Toll Like Receptor Adaptor Molecule 1 (TICAM1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Toll Like Receptor Adaptor Molecule 1 (TICAM1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the TICAM1 ticam1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Toll Like Receptor Adaptor Molecule 1 (TICAM1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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