Rabbit anti-Human Rap Guanine Nucleotide Exchange Factor 1 (RAPGEF1) Polyclonal Antibody | anti-RAPGEF1 antibody
Biotin-Linked Polyclonal Antibody to Rap Guanine Nucleotide Exchange Factor 1 (RAPGEF1)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Description
RAPGEF1: an adaptor-type Src homology (SH)2-containing molecule. A guanine nucleotide releasing protein for Ras. Expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants have been described.
Protein type: GEF; GEF, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 9q34.13
Cellular Component: cytoplasm; cytosol; early endosome; endosome; intracellular membrane-bound organelle; perinuclear region of cytoplasm; phagocytic vesicle membrane; protein complex
Molecular Function: guanyl-nucleotide exchange factor activity; protein binding; Rap guanyl-nucleotide exchange factor activity; SH3 domain binding
Biological Process: activation of MAPKK activity; blood vessel development; cellular response to cAMP; negative regulation of canonical Wnt signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of neural precursor cell proliferation; negative regulation of protein kinase B signaling cascade; negative regulation of Ras protein signal transduction; nerve growth factor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of GTPase activity; positive regulation of neuron projection development; Rap protein signal transduction; regulation of JNK cascade; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on RAPGEF1
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Product Notes
The RAPGEF1 rapgef1 (Catalog #AAA2093488) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Biotin-Linked Polyclonal Antibody to Rap Guanine Nucleotide Exchange Factor 1 (RAPGEF1) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Rap Guanine Nucleotide Exchange Factor 1 (RAPGEF1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the RAPGEF1 rapgef1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Rap Guanine Nucleotide Exchange Factor 1 (RAPGEF1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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