Human Multimerin 1 (MMRN1) ELISA Kit | MMRN1 elisa kit
Human Multimerin 1 (MMRN1) Mini Samples ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
Multimerin is a massive, soluble protein found in platelets and in the endothelium of blood vessels. It is comprised of subunits linked by interchain disulfide bonds to form large, variably sized homomultimers. Multimerin is a factor V/Va-binding protein and may function as a carrier protein for platelet factor V. It may also have functions as an extracellular matrix or adhesive protein. Recently, patients with an unusual autosomal-dominant bleeding disorder (factor V Quebec) were found to have a deficiency of platelet multimerin. [provided by RefSeq, Jul 2008]
Uniprot Description
MMRN1: Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. Deficiency in multimerin-1 due to proteolytic degradation within the platelet alpha granules is associated with an autosomal dominant bleeding disorder (factor V Quebec). 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component: extracellular matrix; extracellular region
Molecular Function: protein binding
Biological Process: cell adhesion; platelet degranulation
Research Articles on MMRN1
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Product Notes
The Human MMRN1 mmrn1 (Catalog #AAA2088011) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2088011 ELISA Kit recognizes Human MMRN1. It is sometimes possible for the material contained within the vial of "Multimerin 1 (MMRN1), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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