Monocyte Chemotactic Protein 4 (MCP4) Protein | MCP4 protein

Eukaryotic Monocyte Chemotactic Protein 4 (MCP4)

Cat. Num. AAA2086702

• Applications: SDS-Page, Western Blot
• Purity: > 95%
• Synonyms: Monocyte Chemotactic Protein 4 (MCP4); Eukaryotic Monocyte Chemotactic Protein 4 (MCP4); CCL13; SCYA13; NCC1; SCYL1; CKb10; Chemokine C-C-Motif Ligand 13; Small Inducible Cytokine Subfamily A(Cys-Cys)Member 13; CK-beta-10; Monocyte chemoattractant 4; MCP4 protein

• Host: Yeast
• Purity/Purification: > 95%
• Form/Format: Freeze-dried powder
• Sequence Length: 98

• Applicable Applications for MCP4 protein: Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)
• Fragment: Phe17~Thr98
• Tag: N-terminal His Tag
• Buffer Formulation: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 5% Trehalose and Proclin300.
• Source Note: Eukaryotic expression
• Organism Species: Human
• Endotoxin Level: <1.0EU per 1ug (determined by the LAL method)
• Isoelectric Point: 10
• Subcellular Location: Secreted
• Usage: Reconstitute in PBS or others.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

SDS-Page

Testing Data

Product Categories/Family for MCP4 protein

Eukaryotic proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4885587
• NCBI GeneID: 6357
• NCBI Accession #: NP_005399.1
• NCBI GenBank Nucleotide #: NM_005408.2
• UniProt Accession #: Q99616; O95689; Q6ICQ6
• Molecular Weight: 10.7kDa; 11kDa
• NCBI Official Full Name: C-C motif chemokine 13
• UniProt Protein Name: C-C motif chemokine 13
• Protein Family: Meiotic coiled-coil protein
• UniProt Gene Name: CCL13
• UniProt Synonym Gene Names: MCP4; NCC1; SCYA13; MCP-4

Uniprot Description

CCL13: Chemotactic factor that attracts monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. Signals through CCR2B and CCR3 receptors. Plays a role in the accumulation of leukocytes at both sides of allergic and non-allergic inflammation. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. May play a role in the monocyte attraction in tissues chronically exposed to exogenous pathogens. By IL1/interleukin-1 and TNF. Widely expressed. Found in small intestine, thymus, colon, lung, trachea, stomach and lymph node. Low levels seen in the pulmonary artery smooth muscle cells. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q12

Molecular Function: CCR chemokine receptor binding; chemokine activity; receptor binding

Biological Process: cell-cell signaling; cellular calcium ion homeostasis; chemotaxis; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; lymphocyte chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of GTPase activity; positive regulation of inflammatory response; regulation of cell shape; signal transduction