Taste Receptor Type 2 Member 38 (TAS2R38) Small Molecule | TAS2R38 small molecule

OVA Conjugated Taste Receptor Type 2 Member 38 (TAS2R38)

Cat. Num. AAA2086569

• Gene Names: TAS2R38; PTC; T2R38; T2R61
• Applications: SDS-Page, Western Blot
• Purity: > 90%
• Synonyms: Taste Receptor Type 2 Member 38 (TAS2R38); OVA Conjugated Taste Receptor Type 2 Member 38 (TAS2R38); PTC; T2R61; Phenylthiocarbamide Tasting; PTC bitter taste receptor; TAS2R38 small molecule

• Host: Protein Conjugation
• Purity/Purification: > 90%
• Form/Format: Freeze-dried powder
• Sequence Length: 333

• Applicable Applications for TAS2R38 small molecule: Immunogen, SDS-PAGE, Western Blot (WB)
• Buffer Formulation: PBS, pH7.4.
• Organism Species: Human
• Usage: Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Sequence Information

SDS-Page

Testing Data

Product Categories/Family for TAS2R38 small molecule

Conjugated small molecules

NCBI and Uniprot Product Information

• NCBI GI #: 261490645
• NCBI GeneID: 5726
• NCBI Accession #: NP_789787.4
• NCBI GenBank Nucleotide #: NM_176817.4
• UniProt Accession #: P59533; P59552; Q2M3E8; Q645W3; Q86UK3; A4D1U6
• Molecular Weight: 37,892 Da
• NCBI Official Full Name: taste receptor type 2 member 38
• NCBI Official Synonym Full Names: taste 2 receptor member 38
• NCBI Official Symbol: TAS2R38
• NCBI Official Synonym Symbols: PTC; T2R38; T2R61
• NCBI Protein Information: taste receptor type 2 member 38
• UniProt Protein Name: Taste receptor type 2 member 38
• Protein Family: Taste receptor
• UniProt Gene Name: TAS2R38
• UniProt Synonym Gene Names: PTC; T2R38; T2R61

NCBI Description

This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]

Uniprot Description

TAS2R38: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. Belongs to the G-protein coupled receptor T2R family.

Protein type: GPCR, T2R family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: integral to membrane; plasma membrane

Molecular Function: bitter taste receptor activity

Biological Process: detection of chemical stimulus involved in sensory perception of bitter taste

Disease: Thiourea Tasting