Rabbit anti-Mouse PHD Finger Protein 8 (PHF8) Polyclonal Antibody | anti-PHF8 antibody
Cy3-Linked Polyclonal Antibody to PHD Finger Protein 8 (PHF8)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a histone lysine demethylase that preferentially acts on histones in the monomethyl or dimethyl states. The encoded protein requires Fe(2+) ion, 2-oxoglutarate, and oxygen for its catalytic activity. Defects in this gene are a cause of mental retardation syndromic X-linked Siderius type (MRXSSD). Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Uniprot Description
PHF8: a PHD finger protein with N(epsilon)-methyl lysine histone demethylase activity. Associated with mental retardation and cleft lip/palate. Its active site is closely related to those of FBXL10 and 11, all of which are selective for di- and mono-methylated lysine. In contrast, the JMJD2 demethylases are selective for tri- and di-methylated lysine.
Protein type: Demethylase; EC 1.14.11.27; Nucleolus
Chromosomal Location of Human Ortholog: Xp11.22
Cellular Component: nuclear membrane; nucleolus; nucleoplasm; nucleus
Molecular Function: chromatin binding; histone demethylase activity; histone demethylase activity (H3-K36 specific); histone demethylase activity (H3-K9 specific); iron ion binding; methylated histone residue binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; protein binding; zinc ion binding
Biological Process: brain development; G1/S transition of mitotic cell cycle; histone H3-K9 demethylation; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription, DNA-dependent
Disease: Siderius X-linked Mental Retardation Syndrome
Research Articles on PHF8
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Product Notes
The PHF8 phf8 (Catalog #AAA2079738) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cy3-Linked Polyclonal Antibody to PHD Finger Protein 8 (PHF8) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's PHD Finger Protein 8 (PHF8) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the PHF8 phf8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PHD Finger Protein 8 (PHF8), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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