Rabbit anti-Rat Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) Polyclonal Antibody | anti-OSTM1 antibody
Cy3-Linked Polyclonal Antibody to Osteopetrosis Associated Transmembrane Protein 1 (OSTM1)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that may be involved in the degradation of G proteins via the ubiquitin-dependent proteasome pathway. The encoded protein binds to members of subfamily A of the regulator of the G-protein signaling (RGS) family through an N-terminal leucine-rich region. This protein also has a central RING finger-like domain and E3 ubiquitin ligase activity. This protein is highly conserved from flies to humans. Defects in this gene may cause the autosomal recessive, infantile malignant form of osteopetrosis. [provided by RefSeq, Jul 2008]
Uniprot Description
OSTM1: Required for osteoclast and melanocyte maturation and function. Defects in OSTM1 are the cause of osteopetrosis autosomal recessive type 5 (OPTB5); also called infantile malignant osteopetrosis 3. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTB5 patients manifest primary central nervous system involvement in addition to the classical stigmata of severe bone sclerosis, growth failure, anemia, thrombocytopenia and visual impairment with optic atrophy.
Protein type: EC 6.3.2.-; Ligase; Membrane protein, integral; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 6q21
Cellular Component: cytoplasm; intracellular membrane-bound organelle; lysosomal membrane; nucleus
Disease: Osteopetrosis, Autosomal Recessive 5
Research Articles on OSTM1
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Product Notes
The OSTM1 ostm1 (Catalog #AAA2067636) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Cy3-Linked Polyclonal Antibody to Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Osteopetrosis Associated Transmembrane Protein 1 (OSTM1) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (ELISA). Researchers should empirically determine the suitability of the OSTM1 ostm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Osteopetrosis Associated Transmembrane Protein 1 (OSTM1), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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