BRD2 recombinant protein

BRD2, 1-455aa, Human, His tag, E Coli

Cat. Num. AAA206001

• Gene Names: BRD2; FSH; NAT; RNF3; FSRG1; RING3; D6S113E; O27.1.1; BRD2-IT1
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: BRD2; 1-455aa; Human; His tag; E Coli; Bromodomain containing 2; D6S113E; FSH; FSRG1; NAT; RING3; RNF3; BRD2 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In phosphate buffered saline (pH 7.4) containing, 10% glycerol, 1mM DTT
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMLQNVTP HNKLPGEGNA GLLGLGPEAA APGKRIRKPS LLYEGFESPT MASVPALQLT PANPPPPEVS NPKKPGRVTN QLQYLHKVVM KALWKHQFAW PFRQPVDAVK LGLPDYHKII KQPMDMGTIK RRLENNYYWA ASECMQDFNT MFTNCYIYNK PTDDIVLMAQ TLEKIFLQKV ASMPQEEQEL VVTIPKNSHK KGAKLAALQG SVTSAHQVPA VSSVSHTALY TPPPEIPTTV LNIPHPSVIS SPLLKSLHSA GPPLLAVTAA PPAQPLAKKK GVKRKADTTT PTPTAILAPG SPASPPGSLE PKAARLPPMR RESGRPIKPP RKDLPDSQQQ HQSSKKGKLS EQLKHCNGIL KELLSKKHAA YAWPFYKPVD ASALGLHDYH DIIKHPMDLS TVKRKMENRD YRDAQEFAAD VRLMFSNCYK YNPPDHDVVA MARKLQDVFE FRYAKMPD
• Sequence Length: 801

• Applicable Applications for BRD2 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for BRD2 recombinant protein

BRD2 is a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of roteins. This protein associates with transcription complexes and ith acetylated chromatin during mitosis, and it selectively binds o the acetylated lysine-12 residue of histone H4 via its two romodomains. The gene maps to the major histocompatability complex MHC) class II region on chromosome 6p21.3, but sequence comparison uggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Recombinant human BRD2 protein, fused to His-tag at N-terminus, was expressed in E Coli.

Product Categories/Family for BRD2 recombinant protein

Signal Transduction

References

Boehm,D., et al. (2013) Cell Cycle 12 (3), 452-462; Tang,X., et al. (2013) Mol. Pharmacol. 83 (1), 283-293;

NCBI and Uniprot Product Information

• NCBI GI #: 4826806
• NCBI GeneID: 6046
• NCBI Accession #: NP_005095
• NCBI GenBank Nucleotide #: NM_005104.3
• UniProt Accession #: P25440; O00699; O00700; Q15310; Q5STC9; Q63HQ9; Q658Y7; Q6P3U2; Q969U4; A2AAU0; B0S7P0; B1AZT1
• Molecular Weight: 52.8kDa (478aa)
• NCBI Official Full Name: bromodomain-containing protein 2 isoform 1
• NCBI Official Synonym Full Names: bromodomain containing 2
• NCBI Official Symbol: BRD2
• NCBI Official Synonym Symbols: FSH; NAT; RNF3; FSRG1; RING3; D6S113E; O27.1.1; BRD2-IT1
• NCBI Protein Information: bromodomain-containing protein 2
• UniProt Protein Name: Bromodomain-containing protein 2
• Protein Family: Bromodomain-containing protein
• UniProt Gene Name: BRD2
• UniProt Synonym Gene Names: KIAA9001; RING3

NCBI Description

This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

Uniprot Description

May play a role in spermatogenesis or folliculogenesis (). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.