SDS-Page
RCAN3 recombinant protein
RCAN3, 56-241aa, Human, His tag, E Coli (Denatured)
Gene Names
RCAN3; RCN3; MCIP3; hRCN3; DSCR1L2
Applications
SDS-Page
Purity
> 90% by SDS-PAGE
Synonyms
RCAN3; 56-241aa; Human; His tag; E Coli (Denatured); Calcipressin-3; DSCR1L2; hRCN3; MCIP3; RCN3; RCAN3 recombinant protein
Host
E Coli
Purity/Purification
> 90% by SDS-PAGE
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 2M urea, 20% glycerol, 0.2M NaCl
Concentration
0.5 mg/ml (determined by Bradford assay) (varies by lot)
Sequence
MGSSHHHHHH SSGLVPRGSH MGSEAVFEAR EQKERFEALF TIYDDQVTFQ LFKSFRRVRI NFSKPEAAAR ARIELHETDF NGQKLKLYFA QVQMSGEVRD KSYLLPPQPV KQFLISPPAS PPVGWKQSED AMPVINYDLL CAVSKLGPGE KYELHAGTES TPSVVVHVCE SETEEEEETK NPKQKIAQTR RPDPPTAALN EPQTFDCAL
Sequence Length
241
Applicable Applications for RCAN3 recombinant protein
SDS-PAGE
Antigen Species
Human
Tag Information
His-tag
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
SDS-Page
SDS-Page
Related Product Information for RCAN3 recombinant protein
Calcipressin-3, also known as RCAN3, is a 241 amino acid protein that potentially is involved in central nervous system development. RCAN3 inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Overexpression of calcipressin-3 results in inhibition of calcineurin activity towards the nuclear factor of activated T-cells (NFAT) transcription factors and also downregulates NFAT-dependent cytokine gene expression in activated Jurkat T-cells. Highest expression occurs in heart, skeletal muscle kidney, liver and peripheral blood leukocytes. Recombinant human RCAN3 protein, fused to His-tag at N-terminus, was expressed in E Coli.
Product Categories/Family for RCAN3 recombinant protein
References
Strippoli P., et al. (2000) Genomics. 64:252-263.; Abbasi S., et al. (2006) J Biol Chem. 281:7717-7726.;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
23.5 kDa (209aa)
NCBI Official Full Name
calcipressin-3 isoform 1
NCBI Official Synonym Full Names
RCAN family member 3
NCBI Official Symbol
RCAN3
NCBI Official Synonym Symbols
RCN3; MCIP3; hRCN3; DSCR1L2
NCBI Protein Information
calcipressin-3
UniProt Protein Name
Calcipressin-3
Protein Family
UniProt Gene Name
RCAN3
UniProt Synonym Gene Names
DSCR1L2; MCIP3
Uniprot Description
Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development ().
Research Articles on RCAN3
1. The tumor suppressor effect of RCAN3 in breast cancer depends on the interaction with calcineurin.
Similar Products
Product Notes
The RCAN3 rcan3 (Catalog #AAA205499) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The tag for this protein is His-tag. AAA Biotech's RCAN3 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the RCAN3 rcan3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MGSSHHHHHH SSGLVPRGSH MGSEAVFEAR EQKERFEALF TIYDDQVTFQ LFKSFRRVRI NFSKPEAAAR ARIELHETDF NGQKLKLYFA QVQMSGEVRD KSYLLPPQPV KQFLISPPAS PPVGWKQSED AMPVINYDLL CAVSKLGPGE KYELHAGTES TPSVVVHVCE SETEEEEETK NPKQKIAQTR RPDPPTAALN EPQTFDCAL. It is sometimes possible for the material contained within the vial of "RCAN3, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
