ANXA8 recombinant protein

ANXA8, 1-327aa, Human, His tag, E Coli

Cat. Num. AAA203745

• Gene Names: ANXA8; ANX8; CH17-360D5.2
• Applications: SDS-Page
• Purity: > 90% by SDS-PAGE
• Synonyms: ANXA8; 1-327aa; Human; His tag; E Coli; Annexin A8; ANX8; Annexin-8; Annexin VII; Vascular anticoagulant-beta; VAC-beta; ANXA8 recombinant protein

• Host: E Coli
• Purity/Purification: > 90% by SDS-PAGE
• Form/Format: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.1M NaCl, 1mM DTT, 1mM EDTA, 10% glycerol
• Concentration: 1 mg/ml (determined by Bradford assay) (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MAWWKSWIEQ EGVTVKSSSH FNPDPDAETL YKAMKGIGTN EQAIIDVLTK RSNTQRQQIA KSFKAQFGKD LTETLKSELS GKFERLIVAL MYPPYRYEAK ELHDAMKGLG TKEGVIIEIL ASRTKNQLRE IMKAYEEDYG SSLEEDIQAD TSGYLERILV CLLQGSRDDV SSFVDPGLAL QDAQDLYAAG EKIRGTDEMK FITILCTRSA THLLRVFEEY EKIANKSIED SIKSETHGSL EEAMLTVVKC TQNLHSYFAE RLYYAMKGAG TRDGTLIRNI VSRSEIDLNL IKCHFKKMYG KTLSSMIMED TSGDYKNALL SLVGSDP
• Sequence Length: 327

• Applicable Applications for ANXA8 recombinant protein: SDS-PAGE
• Antigen Species: Human
• Tag Information: His-tag
• Preparation and Storage: Can be stored at 4 degree C short term (1-2 weeks).; For long term storage, aliquot and store at -20 degree C or -70 degree C.; Avoid repeated freezing and thawing cycles.

SDS-Page

Related Product Information for ANXA8 recombinant protein

ANXA8, also known as Annexin A8, a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. Where co-expressed in the same tissues, ANXA8 is often expressed at a 100-fold lower level than Annexin A5. However, ANXA8 is preferentially expressed in acute promyelocytic leukemia (APL) cells which may relate to its role in hematopoietic cell differentiation. Recombinant human ANXA8 protein, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques.

Product Categories/Family for ANXA8 recombinant protein

Signal Transduction

References

Movitz C., et al. (2010) J Biol Chem. 285 (19):14338-45.; Torosyan Y., et al. (2010) Oncogene. 29 (17):2457-66.;

NCBI and Uniprot Product Information

• NCBI GI #: 91823262
• NCBI GeneID: 653145
• NCBI Accession #: NP_001035173
• NCBI GenBank Nucleotide #: NM_001040084.2
• UniProt Accession #: P13928; Q5T2P8; Q5VTM4; Q6GMY3; Q9BT34; A6NDE6; A6NLM1; B4DKI1; B4DTC9
• Molecular Weight: 39.0 kDa (347aa), confirmed by MALDI-TOF
• NCBI Official Full Name: annexin A8 isoform 2
• NCBI Official Synonym Full Names: annexin A8
• NCBI Official Symbol: ANXA8
• NCBI Official Synonym Symbols: ANX8; CH17-360D5.2
• NCBI Protein Information: annexin A8
• UniProt Protein Name: Annexin A8
• Protein Family: Annexin
• UniProt Gene Name: ANXA8
• UniProt Synonym Gene Names: VAC-beta

NCBI Description

This gene encodes a member of the annexin family of evolutionarily conserved Ca2+ and phospholipid binding proteins. The encoded protein may function as an an anticoagulant that indirectly inhibits the thromboplastin-specific complex. Overexpression of this gene has been associated with acute myelocytic leukemia. A highly similar duplicated copy of this gene is found in close proximity on the long arm of chromosome 10. [provided by RefSeq, Jul 2008]

Uniprot Description

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.