Dystrobrevin Binding Protein 1 Recombinant Protein | DTNBP1 recombinant protein

Recombinant Dystrobrevin Binding Protein 1 (DTNBP1)

Cat. Num. AAA2034375

• Gene Names: DTNBP1; SDY; DBND; HPS7; My031; BLOC1S8
• Reactivity: Mouse
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Dystrobrevin Binding Protein 1; Recombinant Dystrobrevin Binding Protein 1 (DTNBP1); DBND; HPS7; My031; SDY; Dysbindin; Biogenesis of lysosome-related organelles complex 1 subunit 8; Hermansky-Pudlak syndrome 7 protein; DTNBP1 recombinant protein

• Host: E Coli
• Reactivity: Mouse
• Purity/Purification: >95%
• Sequence Length: 351

• Applicable Applications for DTNBP1 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Fragment: Gln179~Glu319
• Tag: Prokaryotic expression
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 15080306
• NCBI GeneID: 84062
• Molecular Weight: 19.5kDa
• NCBI Official Full Name: Dystrobrevin binding protein 1
• NCBI Official Synonym Full Names: dystrobrevin binding protein 1
• NCBI Official Symbol: DTNBP1
• NCBI Official Synonym Symbols: SDY; DBND; HPS7; My031; BLOC1S8
• NCBI Protein Information: dysbindin
• UniProt Protein Name: Dysbindin
• Protein Family: Dysbindin
• UniProt Gene Name: DTNBP1
• UniProt Synonym Gene Names: BLOC1S8; BLOC-1 subunit 8; HPS7 protein
• UniProt Entry Name: DTBP1_HUMAN

NCBI Description

This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. A similar protein in mouse is a component of a protein complex termed biogenesis of lysosome-related organelles complex 1 (BLOC-1), and binds to alpha- and beta-dystrobrevins, which are components of the dystrophin-associated protein complex (DPC). Mutations in this gene are associated with Hermansky-Pudlak syndrome type 7. This gene may also be associated with schizophrenia. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

DTNBP1: The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. May be required for normal dopamine homeostasis in the cerebral cortex, hippocampus, and hypothalamus. Plays a role in the regulation of cell surface exposure of DRD2. Contributes to the regulation of dopamine signaling. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Part of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). The BLOC-1 complex is composed of BLOC1S1, BLOC1S2, BLOC1S3, DTNBP1, MUTED, PLDN, CNO/cappuccino and SNAPIN. Binds to DTNA and DTNB but may not be a physiological binding partner (PubMed:16980328). Interacts with RNF151 and CMYA5. Identified in a complex with the adapter-related protein complex 3 (AP-3). Interacts with TRIM32, AP3M1 and AP3B2. Identified in a complex with the biogenesis of lysosome-related organelles complex 2 (BLOC-2). Interacts with the DNA-dependent protein kinase complex DNA-PK. Detected in brain, in neurons and in neuropil. Detected in dentate gyrus and in pyramidal cells of hippocampus CA2 and CA3. Belongs to the dysbindin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle

Chromosomal Location of Human Ortholog: 6p22.3

Cellular Component: axon; cell junction; cytoplasm; cytosol; dendritic spine; endoplasmic reticulum membrane; endosome membrane; growth cone; melanosome membrane; neuron projection; nucleus; postsynaptic density; postsynaptic membrane; sarcolemma; sarcoplasm; synaptic vesicle membrane

Molecular Function: protein binding

Biological Process: actin cytoskeleton reorganization; anterograde axon cargo transport; anterograde synaptic vesicle transport; blood coagulation; melanosome organization and biogenesis; neurite development; neurite morphogenesis; platelet dense granule organization and biogenesis; positive regulation of neurotransmitter secretion; post-Golgi vesicle-mediated transport; regulation of dopamine receptor signaling pathway; regulation of dopamine secretion; regulation of JNK activity

Disease: Hermansky-pudlak Syndrome 7; Schizophrenia