Sequence Information
Von Willebrand Factor Cleaving Protease Recombinant Protein | vWFCP recombinant protein
Recombinant Von Willebrand Factor Cleaving Protease (vWFCP)
(May be suitable for use in other assays to be determined by the end user.)
Predicted Molecular Mass: 55.4kDa
Accurate Molecular Mass: 55kDa as determined by SDS-PAGE reducing conditions
Store at 2-8 degree C for one month.
Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition.
Sequence Information
Sequence Information
SDS-Page
SDS-Page
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Description
ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.24.87; Extracellular matrix; Secreted; Calcium-binding; Motility/polarity/chemotaxis; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9q34
Cellular Component: cell surface; endoplasmic reticulum lumen; extracellular space; proteinaceous extracellular matrix
Molecular Function: calcium ion binding; integrin binding; metalloendopeptidase activity; metallopeptidase activity; protein binding; zinc ion binding
Biological Process: cell-matrix adhesion; cellular protein metabolic process; glycoprotein metabolic process; integrin-mediated signaling pathway; peptide catabolic process; platelet activation; post-translational protein modification; protein amino acid O-linked glycosylation; protein processing; proteolysis; response to toxin
Disease: Thrombotic Thrombocytopenic Purpura, Congenital
Research Articles on vWFCP
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Product Notes
The vWFCP adamts13 (Catalog #AAA2034172) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Von Willebrand Factor Cleaving Protease (vWFCP) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Von Willebrand Factor Cleaving Protease can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling. (May be suitable for use in other assays to be determined by the end user.) . Predicted isoelectric point: 6.4 Predicted Molecular Mass: 55.4kDa Accurate Molecular Mass: 55kDa as determined by SDS-PAGE reducing conditions . Researchers should empirically determine the suitability of the vWFCP adamts13 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Von Willebrand Factor Cleaving Protease, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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