Snurportin 1 Recombinant Protein | SNUPN1 recombinant protein

Recombinant Snurportin 1 (SNUPN1)

Cat. Num. AAA2033212

• Gene Names: SNUPN; KPNBL; RNUT1; Snurportin1
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 90%
• Synonyms: Snurportin 1; Recombinant Snurportin 1 (SNUPN1); SPN1; KPNBL; RNUT1; RNA; U Transporter 1; SNUPN1 recombinant protein

• Host: E Coli
• Purity/Purification: > 90%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Sequence: MEELSQALAS SFSVSQELNS TAAPHPRLCQ YKSKYSSLEQ SERRRQLLELQKSKRLDYVN HARRLAEDDW TGMESGEEEN KKDEEEMDID PSKKLPKRYANQLMLSEWLI DVPSDLGQEW IVVVCPVGKR ALIVASRGST SAYTKSGYCVNRFSSLLPGG NRRNSTTAKD YTILDCIYSE VNQTYYVLDV MCWRGHPFYDCQTDFRFYWM HSKLPEEEGL GEKTKINPFK FVGLKNFPCT PESLCEVLSMDFPFEVDGLL FYHKQTHYSP GSTPLVGWLR PYMVSDILGV AVPAGPLTTKPEYAGHQLQQ IIEHKRSQED TKEKLTHKA
• Sequence Length: 360

• Applicable Applications for SNUPN1 recombinant protein: SDS-PAGE, Western (WB), ELISA (EIA), Immunoprecipitation (IP).
• Predicted Molecular Mass: 41.4kDa
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Endotoxin Level: <1.0EU per 1 ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Fragment: Met1~Ala329
• Organism Species: Mouse
• Tag: two N-terminal Tags, His-tag and T7-tag
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 13278885
• NCBI GeneID: 10073
• Molecular Weight: 41,143 Da
• NCBI Official Full Name: Snurportin 1
• NCBI Official Synonym Full Names: snurportin 1
• NCBI Official Symbol: SNUPN
• NCBI Official Synonym Symbols: KPNBL; RNUT1; Snurportin1
• NCBI Protein Information: snurportin-1
• UniProt Protein Name: Snurportin-1
• UniProt Gene Name: SNUPN
• UniProt Synonym Gene Names: RNUT1; SPN1
• UniProt Entry Name: SPN1_HUMAN

NCBI Description

The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RNUT1: Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs. Belongs to the snurportin family.

Protein type: Nuclear import; RNA-binding

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: cytosol; nuclear pore

Molecular Function: protein transporter activity; RNA cap binding

Biological Process: gene expression; protein import into nucleus; spliceosomal snRNP biogenesis