Transforming Growth Factor Beta Receptor III Recombinant Protein | TGFbR3 recombinant protein

Recombinant Transforming Growth Factor Beta Receptor III (TGFbR3)

Cat. Num. AAA2030494

• Gene Names: TGFBR3; BGCAN; betaglycan
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Transforming Growth Factor Beta Receptor III; Recombinant Transforming Growth Factor Beta Receptor III (TGFbR3); TGFbR3 recombinant protein

• Host: Host: E Coli; Source: Prokaryotic expression
• Purity/Purification: >95%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Concentration: 5.8 (varies by lot)
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and GST-tag, its sequence is listed below.; MSPILGYWKI KGLVQPTRLL LEYLEEKYEE HLYERDEGDK WRNKKFELGL EFPNLPYYID GDVKLTQSMA IIRYIADKHN MLGGCPKERA EISMLEGAVL DIRYGVSRIA YSKDFETLKV DFLSKLPEML KMFEDRLCHK TYLNGDHVTH PDFMLYDALD VVLYMDPMCL DAFPKLVCFK KRIEAIPQID KYLKSSKYIA WPLQGWQATF GGGDHPPKSD GSTSGSGHHH HHHSAGLVPR GSTAIGMKET AAAKFERQHM DSPDLGTGGG SGIEGRGSMG YRGSEF-FQ TNGYSGMELT LLDPSCKAKM NGTHFVLESP LNGCGTRHRR SAPDGVVYYN SIVVQAPSPG DSSGWPDGYE DLESGDNGFP GDTDEGETAP LSRAGVVVFN CSLRQLRSPS GFQDQLDGNA TFNMELYNTD LFLVPSPGVF SVAENEHVYV EVSVTKADQD LGFAIQTCFI SPYSNPDRMS DYTIIENICP KDDSVKFYSS KRVHFPIPHA EVDKKRFSFV FKSVFNTSLLFLHCELTLCS RNKGSQKLPK CVTP
• Sequence Length: 850

• Applicable Applications for TGFbR3 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Predicted Molecular Mass: 60.7kDa
• Accurate Molecular Mass (KD): 58kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Tag: two N-terminal Tags, His-tag and GST-tag
• Organism Species: Mus musculus (Mouse)
• Fragment: Phe469~Pro724
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 307574691
• NCBI GeneID: 7049
• NCBI Accession #: NP_001182612.1
• NCBI GenBank Nucleotide #: NM_001195683.1
• Molecular Weight: 93,428 Da
• NCBI Official Full Name: transforming growth factor beta receptor type 3 isoform b
• NCBI Official Synonym Full Names: transforming growth factor, beta receptor III
• NCBI Official Symbol: TGFBR3
• NCBI Official Synonym Symbols: BGCAN; betaglycan
• NCBI Protein Information: transforming growth factor beta receptor type 3
• UniProt Protein Name: Transforming growth factor beta receptor type 3
• Protein Family: Transforming growth factor
• UniProt Gene Name: TGFBR3
• UniProt Synonym Gene Names: TGF-beta receptor type 3; TGFR-3; TGF-beta receptor type III
• UniProt Entry Name: TGBR3_HUMAN

NCBI Description

This locus encodes the transforming growth factor (TGF)-beta type III receptor. The encoded receptor is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[provided by RefSeq, Sep 2010]

Uniprot Description

TGFBR3: Binds to TGF-beta. Could be involved in capturing and retaining TGF-beta for presentation to the signaling receptors. Interacts with TCTEX1D4. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: extracellular space; proteinaceous extracellular matrix; cell surface; integral to plasma membrane; endoplasmic reticulum; receptor complex; external side of plasma membrane

Molecular Function: heparin binding; transforming growth factor beta receptor activity; protein binding; fibroblast growth factor binding; glycosaminoglycan binding; transforming growth factor beta binding; punt binding; activin binding; coreceptor activity; SMAD binding; transforming growth factor beta receptor binding; PDZ domain binding

Biological Process: transforming growth factor beta receptor complex assembly; heart morphogenesis; blood vessel development; organ regeneration; blastocyst development; cell migration; positive regulation of transforming growth factor beta receptor signaling pathway; cardiac muscle cell proliferation; negative regulation of cell motility; palate development; liver development; activation of NF-kappaB transcription factor; BMP signaling pathway; regulation of protein binding; transforming growth factor beta receptor signaling pathway; response to hypoxia; epithelial to mesenchymal transition; ventricular cardiac muscle morphogenesis; immune response; negative regulation of transforming growth factor beta receptor signaling pathway; cell growth; response to follicle-stimulating hormone stimulus; negative regulation of epithelial cell proliferation